Publications

2011:

• Smirnova, T., Adomako, A., Locker, J., Van Rooijen, N., Prystowsky, M.B., Segall, J.E. , 2011. In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. Am. J. Pathol.. vol. 178. pp. 2857-2865. (#613)



• Narasaraju, T.A., Yang, E., Samy, R.P., Ng, H.H., Poh, W.P., Liew, A.A., Phoon, M.C., Van Rooijen, N., Chow, V.T.K. , 2011. Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am. J. Pathol.. vol. 179. pp. 199-210. (#612)



• Kinloch, R.D., Lee, C-M., Van Rooijen, N., Morgan, E.T. , 2011. Selective role for tumor necrosis factor-alpha, but not interleukin-1 of Kupffer cells, in down regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen. Biochem. Pharm. . vol. 82. pp. 312-321. (#611)



• Dorr, A.D., Wilson, M.R., Wakabayashi, K., Waite, A.C., Patel, B.V., Van Rooijen, N., O’Dea, K.P., Takata, M. , 2011. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. J. Appl. Physiol.. vol. 111. pp. 177-184. (#610)



• Cheng, C.W., Duwaerts, C.C., Van Rooijen, N., Wintermeyer, P., Mott, S., Gregory, S.H. , 2011. NK cells suppress experimental cholestaticliver injury by an interleukin-6-mediated, Kupffer cell- dependent mechanism. J. Hepatol.. vol. 54. pp. 746-752. (#609)



• Arias, K., Chu, D.K., Flader, K., Botelho, F., Walker, T., Arias, N., Humbles, A.A., Coyle, A.J., Oettgen, H.C., Chang, H-D., Van Rooijen, N., Waserman, S., Jordana, M. , 2011. Distinct immune-effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J. Allergy Clin. Immun. . vol. 127. pp. 1552-1561. (#608)



• McGaha, T.L., Chen, Y., Ravishankar, B., Van Rooijen, N., Karlsson, M.C. , 2011. Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. Blood. vol. 117. pp. 5403-5412. (#607)



• Cook, P.C., Aynsley, S.A., Turner, J.D., Jenkins, G.R., Van Rooijen, N., Leeto, M., Brombacher, F., Mountford, A.P. , 2011. Multiple helminth infection of the skin causes lymphocyte hyporesponsiveness mediated by Th2 conditioning of dermal myeloid cells . PLoS Pathog.. vol. 7(3). pp. e1001323. (#606)



• Murphy, E.A., Davis, J.M., McClellan, J.L., Carmichael, M.D., Van Rooijen, N., Gangemi, J.D. , 2011. Susceptibility to infection and inflammatory response following influenza virus (H1N1, A/PR/8/34) challenge: Role of macrophages. J. Interferon Cytokine Res.. vol. 31. pp. 501-508. (#605)



• Hashimoto, D., Chow, A., Greter, M., Saenger, Y., Kwan, W-H., Leboeuf, M., Ginhoux, F., Ochando, J.C., Kunisaki, Y., Van Rooijen, N., Liu, C., Teshima, T., Heeger, P.S., Stanley, E.S., Frenette, P.S., Merad, M. , 2011. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J. Exp. Med.. vol. 208. pp. 1069-1082. (#604)



• Soderquest, K., Powell, N., Luci, C., Van Rooijen, N., Hidalgo, A., Geissmann, F., Walzer, T., Lord, G.M., Martin-Fontecha, A. , 2011. Monocytes control natural killer cell differentiation to effector phenotypes. Blood. vol. 117. pp. 4511-4518. (#603)



• Potteau, S., Gautier, E.L., Hutchison, S.B., Van Rooijen, N., Rader, D.J., Thomas, M.J., Sorci-Thomas, M.G., Randolph, G.J. , 2011. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of apoE-/- mice during disease regression. J. Clin. Invest. . vol. 121. pp. 2025-2036. (#602)



• Alexander, K.A., Chang, M.K., Maylin, E.R., Kohler, T., Muller, R., Wu, A.C., Van Rooijen, N., Sweet, M.J., Hume, D.A., Raggatt, L.J., Pettit, A.R., 2011. Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J. Bone Miner. Res.. vol. 26.. pp. 1517-1532. (#601)



• Miyairi, I., Laxton, J.D., Wang, X., Obert, C.A., Venkat, R.R., Tatireddigari, A., Van Rooijen, N., Hatch, T.P., Byrne, G.I., 2011. Chlamydia psittaci genetic variants differ in virulence by modulation of host immunity. J. Infect. Dis.. vol. 204. pp. 654-663. (#600)



• Markovic, D.S., Vinnakota, K., Van Rooijen, N., Kiwit, J., Synowitz, M., Glass, R., Kettenmann, H. , 2011. Minocycline reduces glioma expansion and invasion by attenuating microglial MT1- MMP expression. Brain Behav. Immun.. vol. 25. pp. 624-628. (#599)



• Wang, C., Wang, H., Ide, K., Wang, Y., Van Rooijen, N., Ohdan, H., Yang, Y.G. , 2011. Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPalpha capable of binding to human CD47. Cell Transplant. vol. 20. pp. 1915-1920. (#598)



• Jonsson, F., Mancardi, D.A., Kita, Y., Karasuyama, H., Iannascoli, B., Van Rooijen, N., Shimizu, T., Daeron, M., Bruhns, P. , 2011. Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest. . vol. 121. pp. 1484-1496. (#597)



• Bhatia, S., Fei, M., Yarlagadda, M., Qi, Z., Akira, S., Saijo, S., Iwakura, Y., Van Rooijen, N., Gibson, G.A., St Croix, C.M., Ray, A., Ray, P., 2011. Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One. vol. 6(1). pp. e15943. (#596)



• Mott, K.R., Gate, D., Zandian, M., Allen, S.J., Rajasagi, N.K., Van Rooijen, N., Chen, S., Arditi, M., Rouse, B.T., Flavell, R.A., Town, T., Ghiasi, H. , 2011. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Invest. Ophth. Vis. Res. . vol. 52. pp. 2321-2333. (#595)



• Chow, A., Lucas, D., Hidalgo, A., Mendez-ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., Van Rooijen, N., Tanaka, M., Merad, M., Frenette, P.S. , 2011. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med.. vol. 208. pp. 261-271. (#594)



• Acquati, F., Bertilaccio, S., Grimaldi, A., Monti, L., Cinquetti, R., Bonetti, P., Lualdi, M., Vidalino, L., Fabbri, M., Sacco, M.G., Van Rooijen, N., Campomenosi, P., Vigetti, D., Passi, A., Riva, C., Capella, C., Sanvito, F., Doglioni, C., Gribaldo, L., Macchi, P., Sica, A., Noonan, D.M., Ghia, P., Taramelli, R., 2011. Microenvironmental control of malignancy exerted by RNASET2. A widely conserved extracellular RNase. Proc. Natl. Acad. Sci. USA. vol. 108. pp. 757-761. (#593)



• Mancardi, D.A., Jonsson, F., Iannascoli, B., Khun, H., Van Rooijen, N., Huerre, M., Daeron, M., Bruhns, P., 2011. The murine high affinity IgG receptor FcgammaRIF is sufficient for autoantibody-induced arthritis. J. Immunol.. vol. 186. pp. 1899-1903. (#592)



• El Bakkouri, K., Descamps, F., De Filette, M., Smet, A., Festjens, E., Birkitt, A., Van Rooijen, N., Verbeek, S., Fiers, W., Saelens, X. , 2011. Universal vaccine based on ectodomain of matrix protein 2 of Influenza A: Fc receptors and alveolar macrophages mediate protection. J. Immunol.. vol. 186. pp. 1022-1031. (#591)



• Kurotaki, D., Kon, S., Bae, K., Ito, K., Matsui, Y., Nakayama, Y., Kanayama, M., Kimura, C., Narita, Y., Nishimura, T., Iwabuchi, K., Mack, M., Van Rooijen, N., Uede, T., Morimoto, J. , 2011. CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. vol. 186. pp. 2229-2237. (#590)



• Johnson, E.E., Buhtoiarov, I.N., Baldeshwiler, M.J., Felder, M.A., Van Rooijen, N., Sondel, P.M., Rakhmilevich, A.L. , 2011. Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in mice. J. Immunotherapy. vol. 34. pp. 76-84. (#589)



• Song, J-M., Van Rooijen, N., Bozja, J., Compans, R., Kang, S-M. , 2011. Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A viruses. Proc. Natl. Acad. Sci. USA. vol. 108. pp. 757-761. (#585)



• Song, J-M., Wang, B-Z., Park, K-M., Van Rooijen, N., Quan, F-S., Kim, M-C., Jin, H-T., Pekosz, A., Compans, R.W., Kang, S-M. , 2011. Influenza virus-like particles containing M2 induce broadly cross protective immunity. PLoS One. vol. 6(1); . pp. e14538. (#584)



• Ramos, P., Guy, E., Chen, N., Proenca, C.C., Gardenghi, S., Casu, C., Follenzi, A., Van Rooijen, N., Grady, R.W., de Sousa, M., Rivella, S. , 2011. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis. Blood. vol. 117. pp. 1379-1389. (#582)



• Oshima, H., Hioki, K., Popivanova, B.K., Oguma, K., Van Rooijen, N., Ishikawa, T-O., Oshima, M., 2011. Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors. Gastroenterology. vol. 140. pp. 596-607. (#581)



• Murray, L.A., Chen, Q., Kramer, M.S., Hesson, D.P., Argentieri, R.L., Peng, X., Gulati, M., Homer, R.J., Russell, T., Van Rooijen, N., Elias, J.A., Hogaboam, C.M., Herzog, E.L. , 2011. TGF-beta driven lung fibrosis is macrophage dependent and blocked by serum amyloid P. Int. J. Biochem. Cell Biol. . vol. 43. pp. 154-162. (#578)



• Kataoka, K., Nishiguchi, K.M., Kaneko, H., Van Rooijen, N., Kachi, S., Terasaki, H. , 2011. The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. Invest. Ophthalmol. Vis. Sci. . vol. 52. pp. 1431-1438. (#576)



• Kanematsu, Y., Kanematsu, M., Kurihara, C., Tada, Y., Tsou, T.L., Van Rooijen, N., Lawton, M.T., Young, W.L., Liang, E.I., Nuki, Y., Hashimoto, T. , 2011. Critical roles of macrophages in the formation of intracranial aneurysm. Stroke. vol. 42. pp. 173-178. (#575)



• Chao, J., Donham, P., Van Rooijen, N., Wood, J.G., Gonzalez, N.C. , 2011. Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Am. J. Respir. Cell Mol. Biol.. vol. 45. pp. 53-61. (#573)



• Chamberlain, C.S., Leiferman, E.M., Frisch, K.E., Wang, S., Yang, X., Van Rooijen, N., Baer, G.S., Brickson, S.L., Vanderby, R., 2011. The influence of macrophage depletion on ligament healing. Connective Tiss. Res.. vol. 52. pp. 203-211. (#568)



• Ianotti, C.A., Clark, M., Horn, K.P., Van Rooijen, N., Silver, J., Steinmetz, M.P. , 2011. A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI. Exp. Neurol.. vol. 230. pp. 3-15. (#548)



• Van Weering H.R.J., Boddeke, H.W.G.M., Vinet, J., Brouwer, N., De Haas, A.H., Van Rooijen, N., Thomsen, A.R., Biber, K.P.H. , 2011. CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus. Hippocampus. vol. 21. pp. 220-232. (#521)

2010:

• Lai, J-F., Zindl, C.L., Duffy, L.B., Atkinson, T.P., Jung, J.W., Van Rooijen, N., Waites, K.B., Krause, D.C., Chaplin, D.D. , 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One. vol. 5(12). pp. e14417. (#587)



• Stienstra, R., Joosten, L.A., Koenen, T., Van Tits, B., Van Diepen, J.A., Van den Berg, S.A., Rensen, P.C., Voshol, P.J., Fantuzzi, G., Hijmans, A., Kersten, S., Muller, M., Van den Berg, W.B., Van Rooijen, N., Wabitsch, M., Kullberg, B.J., Van der Meer, J.W., Kanneganti, T., Tack, C.J., Netea, M.G. , 2010. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab.. vol. 12. pp. 593-605. (#586)



• Archambaud, C., Salcedo, S.P., Lelouard, H., Devilard, E., de Bovis, B., Van Rooijen, N., Gorvel, J.P., Malissen, B. , 2010. Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection. Eur. J. Immunol.. vol. 40. pp. 3458-3471. (#583)



• Feig, J.E., Pineda-Torra, I., Sanson, M., Bradley, M.N., Vengrenyuk, Y., Bogunovic, D., Gautier, E.L., Rubinstein, D., Hong, C., Liu, J., Wu, C., van Rooijen, N., Bhardwaj, N., Garabedian, M.J., Tontonoz, P., Fisher, E.A., 2010. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J. Clin. Invest. . vol. 120. pp. 4415-4424. (#580)



• Arwert, E.N., Lal, R., Quist, S., Rosewell, I., van Rooijen, N., Watt, F.M. , 2010. Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc. Natl. Acad. Sci. USA. vol. 107. pp. 19903-19908. (#579)



• Wunderlich, F.T., Strohle, P., Konner, A.C., Gruber, S., Tovar, S., Bronneke, H.S., Juntti-Berggren, L., Li, L.S., Van Rooijen, N., Libert, C., Berggren, P.O., Bruning, J.C. , 2010. Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. Cell Metab.. vol. 12. pp. 237-249. (#574)



• Frimpong-Boateng, K., van Rooijen, N., Geiben-Lynn, R. , 2010. Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8 T cell immune response by the cytokine TGFbeta. PLoS One. vol. 5(8). pp. e12281. (#572)



• Detalle, L., Su, D., Van Rooijen, N., Coutelier, J-P., 2010. Immunoglobulin M antiplatelet autoantibodies from mice immunized with rat platelets induce thrombocytopenia and platelet function impairment. Exp. Biol. Med.. vol. 235. pp. 1464-1471. (#571)



• Fabricio, K., Manix, c., Tian, H., Van Rooijen, N., Pirofski, L.A., 2010. The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages . Vaccine. vol. 28. pp. 7542-7550. (#570)



• Weisel, F.J., Appelt, U.K., Schneider, A.M., Horlitz, J.U., Van Rooijen, N., Korner, H., Mach, M., Winkler, T.H., 2010. Unique requirements for reactivation of virus-specific memory B lymphocytes. J. Immunol.. vol. 185. pp. 4011-4021. (#569)



• Mount, A.M., Masson, F., Kupresanin, F., Smith, C.M., May, J.S., Van Rooijen, N., Stevenson, P.G., Belz, G.T. , 2010. Interference with dendritic cell populations limits early antigen presentation in chronic {gamma}- Herpesvirus-68 infection. J. Immunol.. vol. 185. pp. 3669-3676. (#567)



• Bradshaw, A., Parker, A., Duffy, M., Coughlan, L., Van Rooijen, N., Kahari, V-M., Nicklin, S., Baker, A. , 2010. Requirements for receptor engagement during infection by Adenovirus complexed with blood coagulation factor X. PLoS Pathog.. vol. 6(10). pp. e1001142. (#565)



• Winkler, I.G., Sims, N.A., Pettit, A.R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I.J., Van Rooijen, N., Alexander, K.A., Raggat, L.J., Levesque, J-P. , 2010. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. vol. 116. pp. 4815-4828. (#564)



• Ly, L.V., Baghat, A., Versluis, M., Jordanova, E.S., Van Rooijen, N., Van Hall, T., Van der Velden, P.A., Jager, M.J. , 2010. In aged mice, outgrowth of intraocular melanoma depends on pro-angionic M2 type macrophages. J. Immunol.. vol. 185. pp. 3481-3488. (#563)



• Ishida, W., Fukuda, K., Kajisako, M., Takahashi, A., Sumi, T., Van Rooijen, N., Fukushima, A. , 2010. Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis. Mol. Vision. vol. 16. pp. 1280-1285. (#562)



• Arnold, l., Kumar Tyagi, R., Mejia, P., Van Rooijen, N., Perignon, J.L., Druilhe, P. , 2010. Analysis of innate defences against Plasmodium falciparum in immunodeficient mice. Malar. J.. vol. 9. pp. 197. (#561)



• Steel, C.D., Kim, W.K., Sanford, L.D., Wellman, L.L., Burnett, S., Van Rooijen, N., Ciavarra, R.P. , 2010. Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. J. Neuroimmunol.. vol. 226. pp. 81-92. (#560)



• Villaran, R.F., Espinosa-Oliva, A.M., Sarmiento, M., de Pablos, R.M., Arguelles, S., Delgado-Cortes, M.J., Sobrino, V., van Rooijen, N., Venero, J.L., Herrera, A.J., Cano. J., Machado, A., 2010. Ulcerative colitis exacerbates LPS-induced damage to the nigral dopaminergic system: Potential risk factor in Parkinson’s disease. J. Neurochem.. vol. 114. pp. 1687-1700. (#559)



• Hylton, D.J., Hoffman, S.M., Van Rooijen, N., Tomlinson, S., Fleming, S.D. , 2010. Macrophage produced IL-12p70 mediates hemorrhage-induced damage in a complement dependent manner. Shock. vol. 34. pp. 467-474. (#558)



• Alba, R., Bradshaw, A.C., Coughlan, L., Denby, L., McDonald, R.A., Waddington, S.N., Buckley, S.M., Greig, J.A., Parker, A.L., Miller, A.M., Wang, H., Lieber, A., Van Rooijen, N., McVey, J.H., Nicklin, S.A., Baker, A.H. , 2010. Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood. vol. 116. pp. 2656-2664. (#557)



• Stritzker, J., Weibel, S., Seubert, C., Gotz, A., Tresch, A., Van Rooijen, N., Oelschlaeger, T.A., Hill, P.J., Gentschev, I., Szalay, A.A. , 2010. Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility. Int. J. Med. Microbiol.. vol. 300. pp. 449-456. (#556)



• Garcia, M.R., Ledgerwood, L., Yang, Y., Xu, J., Lal, G., Burrell, B., Ma, G., Hashimoto, D., Li, Y., Boros, P., Grisotto, M., Van Rooijen, N., Matesanz, R., Tacke, F., Ginhoux, F., Ding, Y., Chen, S-H., Randolph, G., Merad, M., Bromberg, J.S., Ochando, J.C. , 2010. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice. J. Clin. Invest. . vol. 120. pp. 2486-2496. (#555)



• Sutherland, M.K., Yu, C., Anderson, M., Zeng, W., Van Rooijen, N., Sievers, E.L., Grewal, I.S., Law, C.L., 2010. 5-Azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia. MAbs. vol. 2. pp. 440-448. (#554)



• Tate, M.D., Pickett, D.L., Van Rooijen, N., Brooks, A.G., Reading, P.C. , 2010. The critical role of airway macrophages in modulating disease severety during influenza virus infection of mice. J. Virol.. vol. 84. pp. 7569-7580. (#553)



• Mitchell, A.J., Pradel, L.C., Chasson, L., Van Rooijen, N., Grau, G.E., Hunt, N.H., Chimini, G. , 2010. Autofluorescence as a tool for myeloid cell analysis. J. Leuk. Biol.. vol. 88. pp. 597-603. (#552)



• Schmaderer, C., Eissler, R., Seibel, S., Van Rooijen, N, Baumann, M. , 2010. Blood pressure control: A facelift for macrophages? . Hypertension. vol. 55. pp. 755-761. (#551)



• Ellett, J.D., Atkinson, C., Evans, Z.P., Amani, Z., Balish, E., Schmidt, M.G., Van Rooijen, N., Schnellmann, R.G., Chavin, K.D. , 2010. Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J. Immunol.. vol. 184. pp. 5849-5858. (#550)



• Barral, P., Polzella, P., Bruckbauer, A., Van Rooijen, N., Besra, G.S., Cerundolo, V., Batista, F.D. , 2010. CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. Nature Immunology. vol. 11. pp. 303-312. (#549)



• Cockburn, I.A., Chen, Y-C. Overstreet, M.G., Lees, J.R., Van Rooijen, N., Farber, D.L., Zavala, F., 2010. Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. PLoS Pathog.. vol. 6(5). pp. e1000877. (#547)



• McGill, J., Van Rooijen, N., Legge, K.L. , 2010. IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J. Exp. Med.. vol. 207. pp. 521-534. (#546)



• Unoki, N., Murakami, T., Nishijima, K., Ogino, K., Van Rooijen, N., Yoshimura, N. , 2010. SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis. Invest. Ophthalmol. Vis. Res. . vol. 51. pp. 3362-3371. (#545)



• Catron, D.M., Pape, K.A., Fife, B.T., Van Rooijen, N., Jenkins, M.K., 2010. A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens. J. Immunol.. vol. 184. pp. 3609-3617. (#544)



• Lang, P.A., Recher, M., Honke, N., Scheu, S., Borkens, S., Gailus, N., Krings, C., Meryk, A., Kulawik, A., Cervantes-Barragan, L., Van Rooijen, N., Kalinke, U., Ludewig, B., Hengartner, H., Harris, N., Haussinger, D., Ohashi, P.S., Zinkernagel, R.M., Lang, K.S. , 2010. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-1-dependent manner in mice. Hepatology. vol. 52. pp. 25-32. (#543)



• Carlos, C.P., Mendes, G.E.F., Miquelin, A.R., Luz, M.A.M., da Silva, C.G.A., Van Rooijen, N., Coimbra, T.M., Burdmann, E.A. , 2010. Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity. Transplantation. vol. 89. pp. 1362-1370. (#542)



• Godbout, C., Bilodeau, R., Van Rooijen, N., Bouchard, P., Frenette, J. , 2010. Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon. J. Orthop. Res.. vol. 28. pp. 1084-1091. (#541)



• Lauro, C., Cipriani, R., Catalano, M., Trettel, F., Chece, G., Brusadin, V., Antonilli, L., Van Rooijen, N., Eusebi, F., Fredholm, B.B., Limatola, C. , 2010. Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology. vol. 35. pp. 1550-1559. (#540)



• Lee, W-Y., Moriarty, T.J., Wong, C., Zhou, H., Strieter, R.M., Van Rooijen, N., Chaconas, G., Kubes, P. , 2010. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nature Immunology. vol. 11. pp. 295-302. (#539)



• Triantafyllopoulou, A., Franzke, C-W., Seshan, S.V., Perino, G., Kalliolias, G.D., Ramanujam, M., Van Rooijen, N., Davidson, A., Ivashkiv, L.B. , 2010. Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc. Natl. Acad. Sci. USA. vol. 107. pp. 3012-3017. (#538)



• Stienstra, S., Saudale, F., Duval, C., Keshtkar, S., Groener, J.E., Van Rooijen, N., Staels, B., Kersten, S., Muller, M. , 2010. Kupffer cells promote hepatic steatosis via interleukin-1 beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology. vol. 51. pp. 511-522. (#537)



• Carmichael, M.D., Davis, J.M., Murphy, E.A., Carson, J.A., Van Rooijen, N., Mayer, E., Ghaffar, A. , 2010. Role of brain macrophages on IL-1 beta and fatigue following eccentric exercise-induced muscle damage. Brain Behav. Immun.. vol. 24. pp. 564-568. (#536)



• Kremer, M., Thomas, E., Milton, R.J., Perry, A.W., Van Rooijen, N., Wheeler, M.D., Zacks, S., Fried, M., Rippe. R.A., Hines, I.N. , 2010. Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology. vol. 51. pp. 130-141. (#535)



• Simon, I.D., Van Rooijen, N., Rose J.K. , 2010. Vesicular stomatitis virus genomic RNA persists in vivo in the absence of viral replication. J. Virol.. vol. 84. pp. 3280-3286. (#534)



• Hunter, M.M., Wang, A., Parhar, K.S., Johnston, M.J.G., Van Rooijen, N., Beck, P.L., McKay, D.M., 2010. In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology. vol. 138. pp. 1395-1405. (#533)



• Machnik, A., Dahlmann, A., Kopp, C., Goss, J., Wagner, H., Van Rooijen, N., Eckardt, K-U., Muller, D.N., Park, J-K., Luft, F.C., Kerjaschki, D., Titze, J. , 2010. Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive binding protein / vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats. Hypertension. vol. 55. pp. 755-761. (#531)



• Reyes, J.L., Terrazas, C.A., Alonso-Trujillo, J., Van Rooijen, N., Satoskar, A.R., Terrazas, L.I. , 2010. Early removal of alternatively activated macrophages leads to Taenia crassiceps cysticercosis clearnce in vivo. Int. J. Parasitol.. vol. 40. pp. 731-742. (#530)



• De Cesare, M., Sfondrini, L., Campiglio, M., Sommariva, M., Bianchi, F., Perego, P., Van Rooijen, N., Supino, R., Rumio, C., Zunino, F., Pratesi, G., Tagliabue, E., Balsari, A. , 2010. Ascites regression and survival increase in mice bearing advanced-stage human ovarian carcinomas and repeatedly treated intraperitoneally with CpG-ODN. J. Immunotherapy. vol. 33. pp. 8-15. (#528)



• Meng, Y., Beckett, M.A., Liang, H., Mauceri, H.J., Van Rooijen, N., Cohen, K., Weichselbaum, R.R. , 2010. Blockade of TNFalpha signaling in tumor-associated macrophages: A new radiosensitizing strategy. Cancer Res.. vol. 70. pp. 1534-1543. (#526)



• Hazlett, L.D., McClellan, S.A., Barrettt, R.P., Huang, X., Zhang, Y., Wu, M., Van Rooijen, N., Szliter, E. , 2010. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas auruginosa keratitis. Invest. Ophthalmol. Vis. Res.. vol. 51. pp. 1524-1532. (#525)



• Serrats, J., Schiltz, J.C., Garcia-Bueno, B., Van Rooijen, N., Reyes, T.M., Sawchenko, P.E. , 2010. Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron. vol. 65. pp. 94-106. (#523)



• Lanthier, N.L., Molendi-Coste, O., Horsmans, Y., Van Rooijen, N., Cani, P.D., Leclercq, I.A. , 2010. Kupffer cell activation is a causal factor for hepatic insulin resistance. Am. J. Physiol.. vol. 298. pp. G107-G116. (#522)



• Mooney, J.E., Rolfe, B.E., Osborne, G.W., Sester, D.P., Van Rooijen, N., Campbell, G.R., Hume, D.A., Campbell, J.H. , 2010. Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. Am. J. Pathol.. vol. 176. pp. 369-380. (#516)



• Luo, J-M., Geng, Y-Q., Zhi, Y., Zhang, M-Z., Van Rooijen, N., Cui, Q. , 2010. Increased intrinsic neuronal vulnerability and decreased beneficial reaction of macrophages on axonal regeneration in aged rats. Neurobiol. Aging. vol. 31. pp. 1003-1009. (#459)



• Van Rooijen, N., Hendrikx, E. , 2010. Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol. Biol. . vol. 605. pp. 189-203. (#456)

2009:

• Ritz, E., Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P.A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., Abraham, W.T., Esler, M., Wang, Y., Tsun, Z., Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.K., Beck, F.X., Muller, D.N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., Van Rooijen, N., Kurtz, A., Hilgers, K.F., Alitalo, K., Eckardt, K.U., Luft, F.C., Kerjaschki, D., Titze, J. , 2009. New approaches to pathogenesis and management of hypertension. Clin. J. Am. Soc. Nephrol.. vol. 4. pp. 1886-1891. (#532)



• Zecher, D., Van Rooijen, N., Rothstein, D.M., Shlomchik, W.D., Lakkis, F.G. , 2009. An innate immune response to allogeneic nonself mediated by monocytes. J. Immunol.. vol. 183. pp. 7810-7816. (#527)



• Kolaczkowska, E., Goldys, A., Kozakiewicz, E., Lelito, M., Plytycz, B., Van Rooijen, N., Arnold, B. , 2009. Resident peritoneal macrophages and mast cells are important cellular sites of COX-1 and COX-2 activity during acute peritoneal inflammation. Arch. Immunol. Ther. Exp.. vol. 57. pp. 459-466. (#524)



• Koh, A.Y., Priebe, G.P., Ray, C., Van Rooijen, N., Pier, G.B. , 2009. Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect. Immun. . vol. 77. pp. 5300-5310. (#520)



• Chung, E-S., Chauhan, S.K., Jin, Y., Nakao, S., Hafezi-Moghadam, A., Van Rooijen, N., Zhang, Q., Chen, L., Dana, R., 2009. Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. Am. J. Pathol.. vol. 175. pp. 1984-1992. (#519)



• Ghulam Muhammad, A.K., Candolfi, M., King, G.D., Yagiz, K., Foulad, D., Mineharu, Y., Kroeger, K.M., Treuer, K.A., Nichols, W.S., Sanderson, N.S., Yang, J., Khayznikov, M., Van Rooijen, N., Lowenstein, P.R., Castro, M.G. , 2009. Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. Clin. Cancer Res.. vol. 15. pp. 6113-6127. (#518)



• Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., De Leval, L., Van Rooijen, N., Le Moine, A., Vanderplasschen, A., Cataldo, D., Drion, P-V., Moser, M., Lekeux, P., Bureau, F. , 2009. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice . J. Clin. Invest. . vol. 119. pp. 3723-3738. (#517)



• Zhao, J., Zhao, J., Van Rooijen, N., Perlman, S. , 2009. Evasion by stealth: Inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. PLoS Pathog.. vol. 5(10). pp. e 1000636. (#515)



• Kurowska-Stolarska, M., Kewin, P., Stolarski, B., Murphy, G., Ying, S., Pitman, N., Mirchandani,A., Rana, B., Van Rooijen, N., McSharry, C., Shepherd, M., McInnes,I.B., Xu, D., Liew, F.Y., 2009. IL-33 amplifies alternatively-activated macrophages that contribute to airway inflammation. J. Immunol.. vol. 183. pp. 6469-6477. (#514)



• McKee, A.S., Munks, M.W., MacLeod, M.K.L., Fleenor, C.J., Van Rooijen, N., Kappler, J.W., Marrack, P. , 2009. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J. Immunol.. vol. 183. pp. 4403-4414. (#513)



• Gyorki, D.E., Asselin-Labat, M-L., Van Rooijen, N., Lindeman, G.L., Visvader, J.E. , 2009. Resident macrophages influence stem cell activity in the mammary gland. Breast Canc. Res. . vol. 11. pp. R62. (#512)