Publications

The following list contains publications of earlier projects. Many of these projects are still in progress.

Click a publication's title to find the abstract on PubMed.

2020:

• Schulte, R., Wohlleber, D., Unrau, I., Geers, B., Metzger, C., Erhardt, A., Tiegs, G., van Rooijen, N., Heukamp, L.C., Klotz, L., Knolle, P.A., Diehl, L. , 2020. Pioglitazone-mediated peroxisome proliferator-activated receptor γ activation aggravates murine immune-mediated hepatitis. . Int. J. Mol. Sci.. vol. 21(7). pp. pii: E2523. (#927)

2019:

• Preston, J.A., Bewley, M.A., Marriott, H.M., McGarry Houghton, A., Mohasin, M., Jubrail, J., Morris, L., Stephenson, Y.L., Cross, S., Greaves, D.R. Craig, R.W. Van Rooijen, N., Bingle, C.D., Read, R.C., Mitchell, T.J., Whyte, M.K.B., Shapiro, S.D., Dockrell, D.H. , 2019. Alveolar macrophage apoptosis-associated bacterial killing helps prevent murine pneumonia. Am. J. Respir. Crit. Care Med.. vol. 200. pp. 84-97. (#926)

2018:

• Bird, T.G., Muller, M., Boulter, L., Vincent, D.F., Ridgway, R.A., Lopez-Guadamillas, E., Lu,W.Y., Jamieson, T., Govaere, O., Campbell, A.D., Ferreira-Gonzalez, S., Cole, A.M., Hay, T., Simpson, K.J., Clark, W., Hedley, A., Clarke, M.,Gentaz, P., Nixon, C., Bryce, S., Kiourtis, C., Sprangers, J., Nibbs, R,J.B., Van Rooijen, N., Bartholin, L., McGreal, S.R., Apte, U., Barry, S.T.,Iredale, J.P., Clarke, A.R., Serrano, M., Roskams, T.A., Sansom, O.J., Forbes, S.J. , 2018. TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translation. Med.. vol. 10. pp. 454. (#923)



• Monajemi, M., Pang, Y., Bjornson, S., Menzies, S., Van Rooijen, N., Sly, L. , 2018. Malt 1 blocks IL-1beta production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo. J. Leuk. Biol.. vol. 104. pp. 557-572. (#922)



• Turner, J.D., Pionnier, N., Furlong-Silva, J., Sjoberg, H., Cross, S., Halliday, A., Guimaraes, A., Cook, D.A.N., Steven, A., Van Rooijen, N., Allen, J.E., Jenkins, S., Taylor, M.J. , 2018. Interleukin-4 activated macrophages mediate immunity to helminth infection by sustaining CCR3-dependent eosinophilia. PLoS Pathog.. vol. 14(3). pp. e1006949. (#920)



• Habiel, D.M., Moreira, A.P., Ismailoglu, U.B., Dunleavy, M.P., Cavassani, K.A., Van Rooijen, N., Coelho, A.L., Hogaboam, C.M. , 2018. TRAIL-dependent resolution of pulmonary fibrosis. Mediators of Inflammation. pp. ID 7934362. (#918)



• Mui, R., Fernandes, R., Garver, H., Van Rooijen, N., Galligan, J. , 2018. Macrophage dependent impairment of alpha2-adrenergic autoreceptor function in sympathic neurons from DOCA-salt but not high fat diet-induced hypertensive rats. Am. J. Physiol. Heart Circ. Physiol.. vol. 314. pp. H863-H877. (#917)



• Shinde, P.V., Xu, H.C., Maney, S.K., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenberg, M., Trilling, M., Pozdeev, V.I., Van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P.R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M., Ruland, J., Mak, T.W., Brenner, D., Pandyra, A.A., Joell, J.I., Borkhardt, A., Häussinger, D., Lang, K.S., Lang, P.A. , 2018. TNF-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection. J. Virol.. vol. 92(3). pp. e01637-17. (#916)



• Schlundt, C., El Khassawna, T., Serra, A., Dienelt, A., Wendler, S., Schell, H., Van Rooijen, N., Radbruch, A.,Lucius, R., Hartmann, S., Duda, G.N., Schmidt-Bleek, K. , 2018. Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone. vol. 106. pp. 78-89. (#905)

2017:

• Davies, M.L., Kaminsky, L.W.,Soni, C., Reider, I.E., Fisher, M.A., Van Rooijen, N., Rahman, Z.S.M., Norbury, C.C. , 2017. A systemic macrophage response is required to contain a peripheral poxvirus infection. PLoS Pathog.. vol. 13(6). pp. e1006435. (#915)



• Lee, A.J., Chen, B., Chew, M.V., Barra, N.G., Shenouda, M.M., Nham, T., Van Rooijen, N., Jordana, M., Mossman, K.L., Schreiber, R.D., Mack, M., Ashkar, A.A. 2017. , 2017. Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during mucosal viral infection. J. Exp. Med.. vol. 214. pp. 1153-1167. (#914)



• Piao, X., Yamazaki, S., Komazawa-Sakon, S., Miyake, S., Nakabayashi, O., Kurosawa, T., Mikami, T., Tanaka, M., Van Rooijen, N., Ohmuraya, M., Oikawa, A., Kojima, Y., Kakuta, S., Uchiyama, Y., Tanaka, M. Nakano, H. , 2017. Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum. Hepatology. vol. 65. pp. 237-252. (#911)



• Van Leeuwen, M.A., Costes, L.M., van Berkel, L.A., Simons-Oosterhuis, Y., Du Pré, M.F., Kozijn, A.E., Raatgeep, H.C., Lindenbergh-Kortleve, D.J., van Rooijen, N., Koning, F., Samsom, J.N. , 2017. Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10 and IFN-gamma-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance. Mucosal Immunol.. vol. 10. pp. 635-649. (#909)



• Gillis, C.M., Jönsson, F., Mancardi, D.A., Beutier, H., Van Rooijen, N., MacDonald, L., Bruhns, P. , 2017. Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice. J. Allergy Clin. Immun. . vol. 139. pp. 1253-1265. (#908)



• Beutier, H., Gillis, C.M., Iannascoli, B., Godon, O., England, P., Sibilano, R., Reber, L.L., Galli, S.J., Cragg, M.S., Van Rooijen, N., Mancardi, D.A., Bruhns, P., Jönsson, F. , 2017. IgG subclasses determine pathways of anaphylaxis in mice. J. Allergy Clin. Immun.. vol. 139. pp. 269-280. (#907)

2016:

• Faraco, G., Sugiyama, Y., Lane, D., Bonilla, L.G., Chang, H., Santisteban, M.M., Racchumu, G., Murphy, M., Van Rooijen, N., Anrather, J., Ladecola, C. , 2016. Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J. Clin. Invest. . vol. 126. pp. 4674-4689. (#913)



• Thompson, H.L., Van Rooijen , N., McLelland, B.T., Manilay, O. , 2016. F4/80+ Host macrophages are a barrier to murine embryonic stem cell-derived hematopoietic progenitor engraftment in vivo. J. Immunol. Res.. vol. 2016. pp. 2414906. (#910)



• Galletti, G., Scielzo, C., Barbaglio, F., Rodriguez, T.V., Riba, M., Lazarevic, D., Cittaro, D., Simonetti, G., Ranghetti, P.,Scarfo, L.,Ponzoni, M., Rocchi, M., Corti, A., Anselmo, A., Van Rooijen, N., Klein, C., Ries, C.H., Ghia, P., De Palma, M., Caligaris-Cappio, F., Bertilaccio, M.T.S. , 2016. Targeting macrophages sensitizes chronic leukemia to apoptosis and inhibits disease progression. Cell Reports. vol. 14. pp. 1748-1760. (#906)



• Ngoh, E.N., Weisser, S.B., Kozicky, L.K., Jen, R., Brugger, H.K., Nackiewicz, D., Van Rooijen, N., Jacobson, K., Ehses, J.A., Turvey, S.E., Sly, L.M. , 2016. Activity of SHIP, which prevents expression of interleukin-1ß, is reduced in patients with Crohn’s disease. Gastroenterology. vol. 150. pp. 465-476. (#902)



• Masuch, A., Shieh, C.H., Van Rooijen, N., Van Calker, D., Biber, K. , 2016. Mechanism of microglia neuroprotection: Involvement of P2X7, TNF alfa and valproic acid. Glia. vol. 64. pp. 76-89. (#898)

2015:

• Shaw, T.N., Stewart-Hutchinson, P.J., Coles, J.A., Van Rooijen, N., Zindy, E., Rodroiguez, A., Brewer, J.M., Couper, K.N., Dustin, M.L., 2015. Perivascular arrest of CD8+ T cells is a signature of experimental cerebral malaria. PLoS Pathog.. vol. 11(11). pp. e1005210. (#904)



• Hitchcock, J.R., Cook, C.N., Bobat, S., Ross, E.A., Flores-Langarica, A., Lowe, K.L.,Khan, M., Dominguez-Medina, C.C., Lax, S., Carvalho-Gaspar, M., Hubscher, S., Rainger, G.E., Cobbold, M., Buckley, C.D., Mitchell, T.J., Mitchell, A., Jones, N.D., Van Rooijen, N., Kirchhofer, D., Henderson, D.H., Adams, D.H., Watson, S.P., Cunningham, A.F., 2015. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J. Clin. Invest. . vol. 125. pp. 4429-4446. (#903)



• Gracey, E., Baglaenko, Y., Prayitno, N., Van Rooijen, N., Akram, A., Lin, A., Chiu, B., Inman, R.D. , 2015. Pulmonary Chlamydia muridarum challenge activates lung interstitial macrophages which correlates with IFN-gamma production and infection control in mice. Eur. J. Immunol.. vol. 45. pp. 3417-3430. (#901)



• Thang, L.V., Demel, S.L., Crawford, R., Kaminski, N.E., Swain, G.M. Van Rooijen, N., Galligan, J.J. , 2015. Macrophage depletion lowers blood pressure and restores sympathetic nerve alpha2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats. Am. J. Physiol. Heart Circ. Physiol.. vol. 309. pp. H1186-1197. (#900)



• Gliem, M., Klotz, L., Van Rooijen, N., Hartung, H-P. Jander, S., 2015. Hyperglycemia and PPARgamma antagonistically influence macrophage polarization and infarct healing after ischemic stroke. Stroke. vol. 46. pp. 2935-2942. (#899)



• Elsegood, C.L., Chan, C.W., Degli-Esposti, M.A., Wikstrom, M.E., Domenichini, A., Lazarus, K., Van Rooijen, N., Ganss, R., Olynyk, J.K., Yeoh, G.C. , 2015. Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration. Hepatology. vol. 62. pp. 1272-1284. (#897)



• Gliem, M., Krammes, K., Liaw, L., Van Rooijen, N., Hartung, H-P., Jander, S. , 2015. Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia. vol. 63. pp. 2198-2207. (#896)



• Mora-Bau, G., Platt, A.M., Van Rooijen, N., Randolph, G.J., Albert, M.L., Ingersoll, M.A. , 2015. Macrophages subvert adaptive immunity to urinary tract infection. PLoS Pathog.. vol. 11(7). pp. e1005044. (#895)



• Schirmer, S.H., Millenaar, D.M., Werner, C., Schuh, L., Degen, A., Bettink, S.I., Lipp, P., Van Rooijen, N., Meyer, T., Böhm, M., Laufs, U. , 2015. Exercise promotes collateral artery growth mediated by monocytic nitric oxide. Arterioscl. Thromb. Vasc. Biol.. vol. 35. pp. 1862-1871. (#894)



• Fougeron, D., Van Maele, L., Songhet, P., Cayet, D., Hot, D., Van Rooijen, N., Mollenkopf, H-J., Hardt, W-D., Benecke, A.G., Sirard, J-C. , 2015. Indirect toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract. Vaccine. vol. 33. pp. 3331-3341. (#893)



• Cha, S-J., Park, K., Srinivasan, P., Schindler, C., Van Rooijen, N., Stins, M., Jacobs-Lorena, M. , 2015. CD68 acts as a major gateway for malaria sporozoite liver infection. J. Exp. Med.. vol. 212. pp. 1391-1403. (#892)



• Roche, J.A., Tulapurkar, M.E., Mueller, A.M., Van Rooijen, N., Hasday, J.D., Lovering, R.M., Bloch, R.J. , 2015. Myofiber damage precedes macrophage infiltration after in vivo injury in Dysferlin-deficient A/J mouse skeletal muscle. Am. J. Pathol.. vol. 185. pp. 1686-1698. (#891)



• Schumak, B., Klocke, K., Kuepper, J.M., Biswas, A., Djie-Maletz, A., Limmer, A., Van Rooijen, N., Msck, M., Hoerauf, A., Dunay, I.R., 2015. Specific depletion of Ly6Chi inflammatory monocytes prevents immunopathology in experimental cerebral malaria. PLoS One. vol. 10(4). pp. e0124080. (#890)



• Benoit, P., Sigounas, V.Y., Thompson, J.L., Van Rooijen, N., Poynter, M.E., Wargo, M.J., Boyson, J.E. , 2015. The role of CD1d-restricted NKT cells in the clearance of P. aeruginosa from the lung is dependent on the host genetic background . Infect. Immun.. vol. 83. pp. 2557-2565. (#889)



• Heymann, F., Peusquens, J., Ludwig-Portugall, I., Kohlhepp, M., Ergen, C., Martin, C., van Rooijen, N., Ochando, J.C., Randolph, G.J., Luedde, T., Ginhoux, F., Kurts, C., Trautwein, C., Tacke, F. , 2015. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology. vol. 62. pp. 279-291. (#888)



• Rawley, O., O’Sullivan, J.M., Chion, A., Keyes, S., Lavin, M., Van Rooijen, N., Brophy, T.M., Fallon, P., Preston, R.J.S., O’Donnell, J.S. , 2015. Von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. J. Thromb. Haemost.. vol. 13. pp. 821-826. (#887)



• Camberlein, E., Cohen, J.M., Jose, R., Hyams, C.J., Callard, R., Chimalapati, S., Yuste, J., Edwards, L.A., Marshall, H., Van Rooijen, N., Noursadeghi, M., Brown, J.S. , 2015. Importance of bacterial replication and alveolar macrophage-independent clearance mechanisms during early lung infection with Streptococcus pneumoniae. Infect. Immun.. vol. 83. pp. 1181-1189. (#886)



• Ford, C.A., Petrova, S., Pound, J.D., Melville, L., Paterson, M., Ogden, C.A., Farnworth, S., Dumitriu, I.E., Dunbar, D.R., Murray, P., Ruckerl, D., Allen, J., Hume, D.A., Van Rooijen, N., Freeman, T., Gregory, C.D. , 2015. Oncogenic properties of apoptotic tumor cells in aggressive B-cell lymphoma. Current Biology. vol. 25. pp. 577-588. (#885)



• Boulter, L., Guest, R., Kendall, T., Wilson, D., Wojtacha, D., Robson, A.,Ridgway, R., Samuel, K., Van Rooijen, N., Barry, S., Wigmore, S., Sansom, O., Forbes, S.J. , 2015. Wnt signaling promotes Cholangiocarcinoma growth and can be therapeutically targeted. J. Clin. Invest. . vol. 125. pp. 1269-1285. (#884)



• Reyes, J.L., Wang, A., Fernando, M.R., Graepel, R., Leung, G., Van Rooijen, N., Sigvardsson, M., McKay, D.M. , 2015. Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages. J. Immunol.. vol. 194. pp. 364-378. (#883)



• Bellner, L., Marrazzo, G., Van Rooijen, N., Dunn, M.W., Abraham, N.G., Schwartzman, M.L. , 2015. Heme oxygenase-2 deletion impairs macrophage function: Implication in corneal wound healing . FASEB J.. vol. 29. pp. 105-115. (#877)



• Alzuguren, P., Hervas-Stubbs, S., Gonzalez-Asequinolaza, G., Poutou, J., Fortes, P., Manchenu, U., Bunuales, M., Olague, C., Razquin, N., Van Rooijen, N., Enguita, M., Hernandez-Alcoceba, R., 2015. Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver. Liver Int.. vol. 35. pp. 1274-1289. (#871)

2014:

• Dominguez-Soto, A., De Las Casas-Engel, M., Bragado, R., Medina-Echeverz, J., Aragoneses-Fenoll, L., Martin-Gayo, E., Van Rooijen, N., Berraondo, P., Toribio, M.L., Moro, M.A., Cuartero, I., Castrillo, A., Sancho, D., Sanchez-Torres, C., Bruhns, P., Sanchez-Ramon, S., Corbi, A.L. , 2014. Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization. J. Immunol.. vol. 193. pp. 5181-5189. (#882)



• Bosmann, M., Russkamp, N,F., Strobl, B., Roewe, J., Balouzian, L., Pache, F., Radsak, M,P., Van Rooijen, N., Zetoune, F.S., Sarma, J.V., Nunez, G., Mueller, M., Murray, P.J., Ward, P.A. , 2014. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J. Immunol.. vol. 193. pp. 5668-5677. (#881)



• Houthuijzen, J.M., Daenen, L.G.M., Roodhart, J.M.L., Oosterom, I., Van Jaarsveld, T.M., Kersbergen, A., Govaert, K.M., Smith, M.E., Thomale, J., Sadatmand, S.J., Rosing, H., Kruse, F., Nijkamp, M.W., Helms, B.J., Van Rooijen, N., Beijnen, J.H., Rottenberg, S., Haribabu, B., Van De Lest, C.H.A., Voest, E.E., 2014. Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. Nature Commun.. vol. 5. pp. Art. 5275. (#880)



• Zaslona, Z., Przybranowski, S., Wilke, C., Van Rooijen, N., Teitz-Tennenbaum, S., Osterholzer, J.J., Wilkinson, J.E., Moore, B.B., Peters-Golden, M. , 2014. Resident alveolar macrophages suppress, whereas recruited monocytes promote allergic lung inflammation in murine models of asthma. J. Immunol.. vol. 193. pp. 4245-4253. (#879)



• Schepens, B., Sedeyn, K., Vande Ginste, L., De Baets, S., Schotsaert, M., Roose, K., Houspie, L., Van Ranst, M., Gilbert, B., Van Rooijen, N., Fiers, W., Piedra, P., Saelens, X. , 2014. Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein. EMBO Mol. Med.. vol. 6. pp. 1436-1454. (#878)



• Lam, R.S., O’Brien-Simpson, N.M., Lenzo, J.C., Holden, J.A., Brammar, G.C., Walsh, K.A., McNaughtan, J.E., Rowler, D.K., Van Rooijen, N., Reynolds, E.C. , 2014. Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice. J. Immunol.. vol. 193. pp. 2349-2362. (#876)



• Weisser, S.B., Kozicky, L.K., Brugger, H.K., Ngoh, E.N., Cheung, B., Jen, R., Menzies, S.C., Samarakoon, A., Murray, P.J., Lim, C.J., Johnson, P., Boucher, J.L., Van Rooijen, N., Sly, L.M. , 2014. Arginase activity in alternatively activated macrophages protects P13Kp110delta deficient mice from dextran sodium sulfate-induced intestinal inflammation. Eur. J. Immunol.. vol. 44. pp. 3353-3367. (#875)



• Narasaraju, T., Yang, E., Samy, R.P., Tan, K.S., Moorthy, A.N., Phoon, M.C., Van Rooijen, N., Choi, H.W., Chow, V.T. , 2014. Combination therapy with hepatocyte growth factor and Oseltamivir confers enhanced protection against influenza viral pneumonia. Current Mol. Med.. vol. 14. pp. 690-702. (#874)



• Grosso, M.J., Matheus, V., Clark, M., Van Rooijen, N., Iannotti, C.A., Steinmetz, M.P. , 2014. Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury. Neurosurgery. vol. 75. pp. 461-471. (#873)



• Tymoszuk, P., Evens, H., Marzola, V., Wachowicz, K., Wasmer, M-H., Datta, S., Muller-Holzner, E., Fiegl, H., Bock, G., Van Rooijen, N., Theurl, I., Doppler, W. , 2014. In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors. Eur. J. Immunol.. vol. 44. pp. 2247-2262. (#872)



• Jacobsen, R.N., Forristal, C.E., Raggatt, L.J., Nowlan, B., Barbier, V., Kaur, S., Van Rooijen, N., Winkler, I.G., Pettit, A.R., Levesque, J.P. , 2014. Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages. Exp. Hematol.. vol. 42. pp. 547-571. (#870)



• Schneider, C., Nobs, S.P., Heer, A.K., Kurrer, M., Klinke, G., Van Rooijen, N., Vogel, J., Kopf, M. , 2014. Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection. PLoS Pathog.. vol. 10(4). pp. e1004053. (#869)



• Arroba, A.L., Alvarez-Lindo, N., Van Rooijen, N., De La Rosa, E.J. , 2014. Microglia-Muller glia crosstalk in the rd10 mouse model of retinitis. Adv. Exp. Med. Biol.. vol. 801. pp. 373-379. (#868)



• Kessler, S.M., Simon, Y., Gemperlein, K., Gianmoena, K., Cadenas, C., Zimmer, V., Pokorny, J., Barghash, A., Helms, V., Van Rooijen, N., Bohle, R.M., Lammert, F., Hengstler, J.G., Mueller, R., Haybaeck, J. Kiemer, A.K., 2014. Fatty acid elongation in non-alcoholic steatothepatitis and hepatocellular carcinoma. Int. J. Mol. Sci. . vol. 15. pp. 5762-5773. (#867)



• Gerlini, A., Colomba, L., Furi, L., Braccini, T., Manso, A.S., Pammolli, A., Wang, B., Vivi, A., Tassini, M., Van Rooijen, N., Pozzi, G., Ricci, S., Andrew, P.W., Koedel, U., Moxon, E.R., Oggioni, M.R., 2014. The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck. PLoS Pathog.. vol. 10(3). pp. e1004026. (#866)



• Winkelmann, E.R., Widman, D.G., Xia, J., Johnson, A.J., van Rooijen, N., Mason, P.W., Bourne, N., Milligan, G.N. , 2014. Subcapsular sinus macrophages limit dissimination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses. Virology. vol. 450-451. pp. 278-289. (#865)



• Pallasch, C.P., Leskov, I., Braun, C.J., Vorholt, D., Drake, A., Soto-Feliciano, Y.M., Bent, E.H., Schwamb, J., Iliopoulou, B., Kutsch, N., van Rooijen, N., Frenzel, L.P., Wendtner, C.M., Heukamp, L., Kreuzer, K.A., Hallek, M., Chen, J., Hemann, M.T. , 2014. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell. vol. 156. pp. 590-602. (#864)



• Rivera, J., Sellers, R.S., Zeng, W., Van Rooijen, N., Casadevall, A., Goldman, D.L. , 2014. Platelet activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem.. vol. 289. pp. 7131-7141. (#863)



• Notari, L., Riera, D.C., Sun, R., Bohl, J.A., McLean, L.P., Madden, K.B., Van Rooijen, N., Vanuytsel, T., Urban, J.F. Jr., Zhao, A., Shea-Donohue, T., 2014. Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection. PLoS One. vol. 9(1). pp. e84763. (#862)



• Killoran, K.E., Miller, A.D. Uray, K.S., Weisbrodt, N.W., Pautler, R.G., Goyert, S.M., Van Rooijen, N., Conner, M.E. , 2014. Role of innate immunity and altered intestinal motility in LPS- and MnCl2- induced intestinal intussusception in mice. Am. J. Physiol. . vol. 306. pp. G445-G453. (#861)



• Cho, S.W., Soki, F.N., Koh, A.J., Eber, M., Entezami, P., Park, S.I., Van Rooijen, N., McCauley, L.K. , 2014. Osteal macrophages support physiologic skeletal remodelling and anabolic actions of parathyroid hormone in bone. Proc. Natl. Acad. Sci. USA. vol. 111. pp. 1545-1550. (#859)



• Filbey, K.J., Grainger, J.R., Smith, K.A., Boon, L., Van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J.P., Maizels, R.M. , 2014. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunol. Cell Biol. . vol. 92. pp. 436-448. (#858)



• De La Durantaye , M., Piette, A.B., Van Rooijen, N., Frenette, J., 2014. Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons. J. Orthop. Res.. vol. 32. pp. 279-285. (#857)



• Sarkar, S., Doring, A., Zemp, F.J., Silva, C., Lun, X.,Wang, X., Kelly, J., Hader, W., Hamilton, M., Mercier, P., Dunn, J.F., Kinniburgh, D., Van Rooijen, N., Robbins, S., Forsyth, P., Cairncross, G., Weiss, S., Yong, V.W. , 2014. Therapeutic activation of macrophages/microglia to suppress brain tumor-initiating cells. Nature Neurosci.. vol. 17. pp. 46-55. (#855)



• Kameka, A.M., Haddadi, S., Jamaldeen, F.J., Moinul, P., He, X.T., Nawazdeen, F.H., Bonfield, S., Sharif, S., Van Rooijen, N., Abdul-Careem, M.F. , 2014. Clodronate treatment significantly depletes macrophages in chickens . Can. J. Vet. Res. . vol. 78. pp. 274-282. (#741)



• Zhou, Z., Sharma, V.P., Beaty, B.T., Roh-Johnson, M., Peterson, E.A., Van Rooijen, N., Kenny, P.A., Wiley, S., Condeelis, J.S., Segall, J.E. , 2014. Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo. Oncogene. vol. 33. pp. 3784-3793. (#734)

2013:

• Cote, C.H., Bouchard, P., Van Rooijen, N., Marsolais, D., Duchesne, E. , 2013. Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury. BMC Musculoskeletal Dis.. vol. 14. pp. 359. (#860)



• Duwaerts, C.C., Sun, E.P., Cheng, C-W., Van Rooijen, N., Gregory, S.H. , 2013. Cross-activating invariant NKT cells and Kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction. PLoS One. vol. 8(11). pp. e79702. (#856)



• Montalvao, F., Garcia, Z., Celli, S., Breart, B., Deguine, J., Van Rooijen, N., Bousso, P. , 2013. The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging. J. Clin. Invest. . vol. 123. pp. 5098-5103. (#746)



• Wu, Y.L., Ye, Q., Eytan, D.F., Liu, L., Rosario, B.L., Hitchens, T.K., Yeh, F-C., Van Rooijen, N., Ho, C. , 2013. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation. Circ. Cardiovasc. Imag.. vol. 6. pp. 965-973. (#745)



• Partecke, L.I., Gunther, C., Hagemann, S., Jacobi, C., Merkel, M., Sendler, M., Van Rooijen, N., Kading, A., Nguyen Trung, D., Lorenz, E., Diedrich, S., Weiss, F.U., Heidecke, C.D., Von Bernstorff, W. , 2013. Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: A quid pro quo in pancreatic cancer. Pancreatology. vol. 13. pp. 508-516. (#744)



• Jakubzick, C., Gautier, E.L., Gibbings, S.L., Sojka, D.K., Schlitzer, A., Johnson, T.E., Ivanov, S., Duan, Q., Bala, S., Condon, T., Van Rooijen, N., Grainger, J.R., Belkaid, Y., Ma’ayan, A., Riches, D.W.H., Yokoyama, W.M., Ginhoux, F., Henson, P.M., Randolph, G.J. , 2013. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity. vol. 39. pp. 599-610. (#742)



• Sennlaub, F., Auvynet, C., Calippe, B., Lavalette, S., Poupel, L., Hu, S.J., Dominguez, E., Camelo, S., Levy, O., Guyon, E., Saederup, N., Charo, I, F., Van Rooijen, N., Nandrot, E., Bourges, J.L., Behar-Cohen, F., Sahel, J.A., Guillonneau, X., Raoul, W., Combadiere, C. , 2013. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol. Med.. vol. 5. pp. 1775-1793. (#740)



• Deppong, C.M., Bricker,T.L., Rannals, B.D., Van Rooijen, N., Hsieh, C-S., Green, J.M., 2013. CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-beta. J. Immunol.. vol. 191. pp. 3082-3089. (#739)



• Potrykus, J., Stead, D., MacCallum, D.M., Urgast, D.S., Raab, A., Van Rooijen, N., Feldmann, J., Brown, A.J.P. , 2013. Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events. PLoS Pathog.. vol. 9(10). pp. e1003676. (#738)



• Ghazarian, L., Diana, J., Beaudoin, L., Larsson, P.G., Puri, R.K., Van Rooijen, N., Flodstrom-Tullberg, M., Lehuen, A. , 2013. Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT cell stimulation: Role of suppressive macrophages. Diabetes. vol. 62. pp. 3785-3796. (#737)



• Jetten, N., Donners, M.M., Wagenaar, A., Cleutjens, J.P., Van Rooijen, N., de Winther, M.P., Post, M.J. , 2013. Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model. PLoS One. vol. 8(7). pp. e68811. (#736)



• Sedlacek, A.L., Gerber, S.A., Randall, T.D., Van Rooijen, N., Frelinger, J.G., Lord, E.M. , 2013. Generation of a dual-functioning antitumor immune response in the peritoneal cavity. Am. J. Pathol.. vol. 183. pp. 1318-1328. (#735)



• Debels, H., Galea, L., Han, X., Palmer, J., Van Rooijen, N., Morrison, W.A., Abberton, K.M., 2013. Macrophages play a key role in angiogenesis and adipogenesis in a mouse tissue engineering model. Tissue Eng. Part A. vol. 19. pp. 2615-2625. (#733)



• Marchiando, A.M., Ramanan, D., Ding, Y., Gomez, L.E., Hubbard-Lucey, V.M., Maurer, K., Wang, C., Ziel, J.W., Van Rooijen, N., Nunez, G., Finlay, B.B., Mysorekar, I.M., Cadwell, K. , 2013. A deficiency in the autophagy gene Atg16L1 enhances resistance to an enteric bacterial infection. Cell Host & Microbe. vol. 14. pp. 216-224. (#732)



• Lebrun, V., Molendi-Coste, O., Lanthier, N., Sempoux, C., Cani, P.D., Van Rooijen, N., Starkel, P., Horsmans, Y., Leclercq, I.A. , 2013. Impact of PPARalpha induction on glucose homeostasis in alcohol-fed mice. Clin. Sci.. vol. 125. pp. 501-511. (#731)



• Publicover, J., Gaggar, A., Nishimura, S., Van Horn, C.M., Goodsell, A., Muench, M.O., Reinhardt, R.L., Van Rooijen, N., Wakil, A.E., Peters, M., Cyster, J.G., Erle, D.J., Rosenthal, P., Cooper, S., Baron, J.L. , 2013. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B virus. J. Clin. Invest. . vol. 123. pp. 3728-3739. (#730)



• Robbins, C.S., Hilgendorf, I., Weber, G.F., Theurl, I., Iwamoto, Y., Figueiredo, J-L., Gorbatov, R., Sukhova, G.K., Gerhardt, L.M.S., Smyth, D., Zavitz, C.J., Shikatani, E.A., Parsons, M., Van Rooijen, N., Lin, H.Y., Husain, M., Libby, P., Nahrendorf, M., Weissleder, R., Swirski, F.K. , 2013. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nature Medicine. vol. 19. pp. 1166-1172. (#729)



• Boross, P., Lohse, S., Nederend, M., Jansen, J.H.M., van Tetering, G., Dechant, M., Peipp, M., Royle, L., Boon, L., van Rooijen, N., Bleeker, W., Parren, P.W.H.I., van de Winkel, J.G., Valerius, T., Leusen, J.H.W. , 2013. IgA EGFR antibodies mediate tumor killing in vivo. EMBO Mol. Med.. vol. 5. pp. 1213-1226. (#728)



• Pires, P.W., Girgla, S.S., McClain, J.L., Kaminski, N.E., Van Rooijen, N., Dorrance, A.M. , 2013. Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypersensitive rats after macrophage depletion. Microcirculation. vol. 20. pp. 650-661. (#727)



• Kruse, J., von Bernstorff, W., Evert, K., Albers, N., Hadlich, S., Hagemann, S., Gunther, C., Van Rooijen, N., Heidecke, C.D., Partecke, L.I., 2013. Macrophages promote tumour growth and liver metastasis in an orthotopic syngeneic mouse model of colon cancer. Int. J. Colorectal Dis.. vol. 28. pp. 1337-1349. (#726)



• De Filippo, K., Dudeck, A., Hasenberg, M., Nye, E., Van Rooijen, N., Hartman, K., Gunzer, M., Roers, A., Hogg, N. , 2013. Mast cell and macrophage chemokines CXCL1 / CXCL2 control the early stage of neutrophil recruitment during tissue inflammation. Blood. vol. 121. pp. 4930-4937. (#725)



• Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M.B., Leboeuf, M., Becker, C.D., See, P., Price, J., Lucas, D., Greter, M., Mortha, A., Boyer, S.W., Forsberg, E.C., Tanaka, M., Van Rooijen, N., Garcia-Sastre, A., Stanley, E.R., Ginhoux, F., Frenette, P.S., Merad, M. , 2013. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. vol. 38. pp. 792-804. (#724)



• Huang, L-R., Wohlleber, D., Reisinger, F., Jenne, C.N., Cheng, R-L., Abdullah, Z., Schildberg, F.A., Odenthal, M., Dienes, H-P., Van Rooijen, N., Schmitt, E., Garbi, N., Croft, M., Kurts, C., Kubes, P., Protzer, U., Heikenwalder, M., Knolle, P.A. , 2013. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection. Nature Immunology. vol. 14. pp. 574-583. (#723)



• Eggenhofer, E., Popp, F.C., Silber, P., Van’t Hof, W., Renner, P., Hoogduijn, M.J., Mendicino, M., Pinxteren, J., Van Rooijen, N., Geissler, E.K., Deans, R., Schlitt, H.J., Dahlke, M.H. , 2013. Heart grafts tolerized through third-party multipotent adult progenitor cells can be re-transplanted to secondary hosts with no immunosuppression . Stem Cells Translational Med. . vol. 2. pp. 595-606. (#722)



• Milo, I., Sapoznikov, A., Kalchenko, V., Tal, O., Krauthgamer, R., Van Rooijen, N., Dudziak, D., Jung, S., Shakhar, G. , 2013. Dynamic imaging reveals promiscuous cross-presentation of blood-borne antigens to naïve CD8+ T cells in the bone marrow. Blood. vol. 122. pp. 193-208. (#721)



• Kawasaki, N., Vela, J.L., Nycholat, C., Rademacher, C., Khurana, A., Van Rooijen, N., Crocker, P.R., Kronenberg, M., Paulson, J.C., 2013. Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust iNKT cell activation. Proc. Natl. Acad. Sci. U S A. vol. 110. pp. 7826-7831. (#720)



• Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., Van Rooijen, N., Tanaka, M., Zhao, Z.J., Bergman, A., Merad, M., Frenette, P.S., 2013. CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nature Medicine. vol. 19. pp. 429-436. (#719)



• Ramos, P., Casu, C., Gardenghi, S., Breda, L., Crielaard, B.J., Guy, E., Marongiu, M.F., Gupta, R., Levina, R.L., Abdel-Wahab, O., Ebert, B.L., Van Rooijen, N., Ghaffari, S., Grady, R.W., Giardina, P.J., Rivella, S. , 2013. Macrophages support pathological erythropoiesis in polycythemia vera and beta-thalassemia. Nature Medicine. vol. 19. pp. 437-445. (#718)



• Casanova-Acebes, M., Pitaval, C., Weiss, L.A., Nombela-Arrieta, C., Chevre, R., A-Gonzalez, N., Kunisaki, Y., Zhang, D., Van Rooijen, N., Silberstein, L.E., Weber, C., Nagasawa, T., Frenette, P.S., Castrillo, A., Hidalgo, A., 2013. Rhytmic modulation of the hematopoietic niche through neutrophil clearance. Cell. vol. 153. pp. 1025-1035. (#717)



• Tavares, J.,Formaglio, P., Thiberge, S., Mordelet, E., Van Rooijen, N., Medvinsky, A., Menard, R., Amino, R. , 2013. Role of host cell traversal by the malaria sporozoite during liver infection. J. Exp. Med.. vol. 210. pp. 905-915. (#716)



• Degos, V., Maze, M., Vacas, S., Hirsch, J., Guo, Y., Shen, F., Jun, K., Van Rooijen, N., Gressens, P., Young, W.L., Su, H., 2013. Bone fracture exacerbates murine ischemic cerebral injury . Anesthesiology. vol. 118. pp. 1362-1372. (#715)



• Villegas-Mendez, A., de Souza, J.B., Lavelle, S-W., Gwyer Findlay, E., Shaw, T.N., Van Rooijen, N., Saris, C.J., Hunter, C.A., Riley, E.M., Couper, K.N., 2013. IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals. PLoS Pathog.. vol. 9(4). pp. e1003293. (#714)