Publications

2013:

• Proskocil, B.J., Bruun, D.A., Jacoby, D.B., Van Rooijen, N., Lein, P.J., Fryer, A.D. , 2013. Macrophage TNF-alpha mediates parathion-induced airway hyperreactivity in guinea pigs. Am. J. Physiol.. vol. 304. pp. L519-L529. (#713)



• Low-Marchelli, J.M., Ardi, V.C., Vizcarra, E.A., Van Rooijen, N., Quigley, J.P., Yang, J. , 2013. Twist1 induces CCL2 and recruits macrophages to promote angiogenesis. Cancer Res.. vol. 73. pp. 662-671. (#712)



• Sfondrini, L., Sommariva, M., Tortoreto, M., Meini, A., Piconese, S., Calvaruso, M., Van Rooijen, N., Bonecchi, R., Zaffaroni, N., Colombo, M.P., Tagliabue, E., Balsari, A. , 2013. Anti-tumor activity of CpG-ODN aerosol in mouse lung metastases. Int. J. Cancer. vol. 133. pp. 383-393. (#711)



• Conrady, C.D., Zheng, M., Van Rooijen, N., Drevets, D.A., Royer, D., Alleman, A., Carr, D.J.J. , 2013. Microglia and a functional type 1 IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J. Immunol.. vol. 190. pp. 2807-2817. (#710)



• Zhou, L., Oh, S.Y., Zhou, Y., Yuan, B., Wu, F., Oh, M.H., Wang, Y., Takemoto, C., Van Rooijen, N., Zheng, T., Zhu, Z. , 2013. SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One. vol. 8(2). pp. e55763. (#709)



• Germano, G., Frapolli, R., Belgiovine, C., Anselmo, A., Pesce, S., Liguori, M., Erba, E., Uboldi, S., Zucchetti, M., Pasqualini, F., Nebuloni, M., van Rooijen, N., Mortarini, R., Beltrame, L., Marchini, S., Fuso Nerini, I., Sanfilippo, R., Casali, P.G., Pilotti, S., Galmarini, C., Anichini, A., Mantovani, A., D’Incalci, M., Allavena, P. , 2013. Role of macrophage targeting in the antitumor activity of Trabectedin. Cancer Cell. vol. 23. pp. 249-262. (#708)



• Duwaerts, C.C., Gehring, S., Cheng, C.W., Van Rooijen, N., Gregory, S.H. , 2013. Contrasting responses of Kupffer cells and inflammatory mononuclear phgocytes to biliary obstruction in a mouse model of cholestatic liver injury. Liver Int.. vol. 33. pp. 255-265. (#707)



• Degos, V., Vacas, S., Han, Z., Van Rooijen, N., Gressens, P., Su, H., Young, W.L., Maze, M. , 2013. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. vol. 118. pp. 527-536. (#706)



• Mancardi, D.A., Albanesi, M., Jonsson, F., Iannascoli, B., Van Rooijen, N., Kang, X., England, P., Daeron, M., Bruhns, P., 2013. The high-affinity human IgG receptor FcgammaRI (CD64) promotes IgG-mediated inflammation, anaphylaxis and anti-tumor immunotherapy. Blood. vol. 121. pp. 1563-1573. (#705)



• Beckett, E.L., Stevens, R.L., Jarnicki, A.G., Kim, R.Y., Hanish, I., Hansbro, N.G., Deane, A., Keely, S., Horvat, J.C., Yang, M., Oliver, B.G., Van Rooijen, N., Inman, M.D., Adachi, R., Soberman, R.J., Hamadi, S., Ward, P.A., Foster, P.S., Hansbro, P.M. , 2013. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J. Allergy Clin. Immun. . vol. 131. pp. 752-762. (#704)



• Swenson-Fields, K.I., Vivian, C.J., Salah, S.M., Peda, J.D., Davis, B.M., Van Rooijen, N., Wallace, D.P., Fields, T.A. , 2013. Macrophages promote polycystic kidney disease progression. . Kidney Int. . vol. 83. pp. 855-864. (#701)



• Zimmerer, J.M., Horne, P.H., Fiessinger, L.A., Fisher, M.G., Jayashankar, K., Garcia, S.F., Abdel-Rasoul, M., Van Rooijen, N., Bumgardner, G.L. , 2013. Inhibition of recall responses through complementary therapies targeting CD8+ T cell- and alloantibody-dependent allocytotoxicity in sensitized transplant recipients. Cell Transplant. vol. 22. pp. 1157-1169. (#700)



• Zheng, G., Zhong, S., Geng, Y., Munirathinam, G., Cha, I., Reardon, C., Getz, G.S., Van Rooijen, N., Kang, Y., Wang, B., Chen, A. , 2013. Dexamethasone promotes tolerance in vivo by enriching CD11c(lo) CD40(lo) tolerogenic macrophages. Eur. J. Immunol.. vol. 43. pp. 219-227. (#696)



• Miura, K., Yang, L., Van Rooijen, N., Brenner, D.A., Ohnishi, H., Seki, E. , 2013. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. vol. 57. pp. 577-589. (#692)



• Kamei, A., Wu, W., Traficante, D.C., Koh, A.Y., Van Rooijen, N., Pier, G.B., Priebe, G.P. , 2013. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. J. Infect. Dis.. vol. 207. pp. 39-49. (#689)



• Kato, J., Okamoto, T., Motoyama, H., Uchiyama, R., Kirchhofer, D., Van Rooijen, N., Enomoto, H., Nishiguchi, S., Kawada, N., Fujimoto, J., Tsutsui, H., 2013. Interferon gamma-mediated tissue factor expression contributes to T cell-mediated hepatitis via induction of hypercoagulation in mice. Hepatology. vol. 57. pp. 362-372. (#688)



• Conrady, C.D., Zheng, M., Mandal, N.A., Van Rooijen, N., Carr, D.J.J. , 2013. IFN-alpha-driven CCL2 production recruits inflammatory monocytes to infection site in mice. Mucosal Immunol.. vol. 6. pp. 45-55. (#675)



• Sendler, M., Dummer, A., Weiss, F.U., Kruger, B., Wartmann, T., Scharffetter-Kochanek, K., Van Rooijen, N., Malla, S.R., Aghdassi, A., Halangk, W., Lerch, M.M., Mayerle, J. , 2013. Tumour necrosis factor alpha secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice. Gut. vol. 62. pp. 430-439. (#658)

2012:

• Weisser, S.B., Van Rooijen, N., Sly, L.M. , 2012. Depletion and reconstitution of macrophages in mice.. Journal of Visualized Experiments. vol. 66. pp. e4105. (#928)



• Duffy, D., Perrin, H., Abadie, V., Benhabiles, N., Boissonnas, A., Liard, C., Descours, B., Reboulleau, D., Bonduelle, O., Verrier, B., Van Rooijen, N., Combadiere, C., Combadiere, B., 2012. Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8(+) T cells. Immunity. vol. 37. pp. 917-929. (#703)



• Piao, X., Komazawa-Sakon, S., Nishina, T., Koike, M., Piao, J-H., Ehlken, H., Kurihara, H., Hara, M., Van Rooijen, N., Schutz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He, Y-W., Nakano, H. , 2012. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Science Signal.. vol. 5(255). pp. ra93. (#702)



• Ebermann, L., Ruzsics, Z., Guzman, C.A., Van Rooijen, N., Casalegno-Garduno, R., Koszinowski, U., Cicin-Sain, L. , 2012. Block of death-receptor apoptosis protects mouse cytomegalovirus from macrophages and is a determinant of virulence in immunodeficient hosts. PLoS Pathog.. vol. 8(12) . pp. e1003062. (#699)



• Grugan, K.D., McGabe, F.L., Kinder, M., Greenplate, A.R., Harman, B.C., Ekert, J.E., VanRooijen, N., Anderson, G.M., Nemeth, J.A., Strohl, W.R., Jordan, R.E., Brezski, R.J., 2012. Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function. J. Immunol.. vol. 189. pp. 5457-5466. (#698)



• Garcia, Z., Lemaitre, F., Van Rooijen, N., Albert, M.L.,Levy, Y., Schwartz, O., Bousso, P. , 2012. Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles. Blood. vol. 120. pp. 4744-4750. (#697)



• Ramachandran, P., Pellicoro, A., Vernon, M.A., Boulter, L., Aucott, R.L., Ali, A., Hartland, S.N., Snowdon, V.K., Cappon, A., Gordon-Walker, T.T., Williams, M.J., Dunbar, D.R., Manning, J.R., Van Rooijen, N., Fallowfield, J.A., Forbes, S.J., Iredale, J.P., 2012. Differential Ly-6C expression identifies the recruited macrophage phenotype which orchestrates the regression of murine liver fibrosis. PNAS Plus. vol. 109. pp. E3186-E3195. (#695)



• Muthupalani, S., Ge, Z., Feng, Y., Rickman, B., Mobley, M., McGabe, A., Van Rooijen, N., Fox, J.G. , 2012. Systemic macrophage depletion inhibits Helicobacter bilis-induced pro-inflammatory cytokine- mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease. Infect. Immun. . vol. 80. pp. 4388-4397. (#694)



• Gliem, M., Hermsen, D., Van Rooijen, N., Hartung, H-P., Jander, S. , 2012. Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: an experimental study in mice. Stroke. vol. 43. pp. 3352-3357. (#693)



• Wohlleber, D., Kashkar, H., Gartner, K., Frings, M.K., Odenthal, M., Hegenbarth, S., Borner, C., Arnold, B., Hammerling, G., Nieswandt, B., Van Rooijen, N., Limmer, A., Cederbrant, K., Heikenwalder, M., Pasparakis, M., Protzer, U., Dienes, H.P., Kurts, C., Kronke, M., Knolle, P.A. , 2012. TNF-induced target cell killing by CTL activated through cross-presentation. Cell Reports. vol. 2. pp. 478-487. (#691)



• Betting, D.J., Hurvitz, S.A., Steward, K.K., Yamada, R.E., Kafi, K., Van Rooijen, N., Timmerman, J.M., 2012. Combination of Cyclophosphamide, Rituximab and intratumoral CpG oligodeoxynucleotide successfully eradicates established B cell lymphoma. J. Immunotherapy. vol. 35. pp. 534-543. (#690)



• Rosetti, F., Tsuboi, N., Chen, K., Nishi, A., Ernandez, T., Sethi, S., Croce, K., Stavrakis, G., Alcocer-Varela, J., Gomez-Martin, D., Van Rooijen, N., Kyttaris, V.C., Lichtman, A., Tsokos, G.C., Mayadas, T.N. , 2012. Human lupus serum induces neutrophil mediated organ damage in mice that is enabled by Mac-1 deficiency. J. Immunol.. vol. 189. pp. 3714-3723. (#687)



• Gautier, E.L., Chow, A., Spanbroek, R., Marcelin, G., Greter, M., Jakubzick, C., Bogunovic, M., Leboeuf, M., Van Rooijen, N., Habenicht, A.J., Merad, M., Randolph, G.J. , 2012. Systemic analysis of PPARgamma in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. J. Immunol.. vol. 189. pp. 2614-2624. (#686)



• Theocharides, A.P.A., Jin, L., Cheng, P-Y., Prasolova, T.K., Malko, A.V., Ho, J.M., Poeppl, A.G., Van Rooijen, N., Minden, M.D., Danska, J.S., Dick, J.E., Wang, J.C.Y. , 2012. Disruption of SIRPalpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J. Exp. Med.. vol. 209. pp. 1883-1899. (#685)



• Coombes, J.L., Han, S.J., Van Rooijen, N., Raulet, D.H., Robey, E.A. , 2012. Infection-induced regulation of natural killer cells by macrophages and collagen at the lymph node subcapsular sinus. Cell Reports. vol. 2. pp. 124-135. (#684)



• Poole, J.A., Gleason, M.A., Bauer, C., West, W.W., Alexis, N., Van Rooijen, N., Reynolds, S.J., Romberger, D.J., Kielian, T., 2012. CD11c+/CD11b+ cells are critical for organic dust-elicited murine lung inflammation. Am. J. Respir. Cell Mol. Biol.. vol. 47. pp. 652-659. (#683)



• Qiu, H., Kuolee, R., Harris, G., Van Rooijen, N., Patel, G.B., Chen, W. , 2012. Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection. PLoS One. vol. 7(6). pp. e40019. (#682)



• Green, N.K., Hale, A., Cawood, R., Illingworth, S., Herbert, C., Hermiston, T.,Subr, V., Ulbrich, K., Van Rooijen, N., Seymour, L.W., Fisher, K.D. , 2012. Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer . Nanomedicine (Lond). vol. 7. pp. 1683-1695. (#681)



• Schiopu, A., Nadig, S.N., Cotoi, O.S., Hester, J., Van Rooijen, N., Wood, K.J. , 2012. Inflammatory Ly-6C(hi) monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients. Atherosclerosis. vol. 223. pp. 291-298. (#680)



• Von Moltke, J., Trinidad, N.J., Moayeri, M., Kintzer, A.F., Wang, S.B., Van Rooijen, N., Brown, C.R., Krantz, B.A., Leppla, S.H., Gronert, K., Vance, R.E. , 2012. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature. vol. 490. pp. 107-111. (#679)



• Coughlan, L., Vallath, S., Gros, A., Gimenez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascallo, M., Alemany, R., Hart, I.R. , 2012. Combined fiber modifications both to target alpha-v-betha-6 and detarget the Coxackievirus-Adenovirus receptor improve virus toxicity profiles in vivo but fail to improve anti-tumoral efficacy relative to Adenovirus serotype 5. Human Gene Therapy. vol. 23. pp. 960-979. (#678)



• Dhaliwal, K., Scholefeld, E., Ferenbach, D., Gibbons, M., Duffin, R., Dorward, D.A., Morris, A.C., Humphries, D., MacKinnon, A., Wilkinson, T.S., Wallace, W.A.H., Van Rooijen, N., Mack, M., Rossi. A.G., Davidson, D.J., Hirani, N., Hughes, J., Haslett, C., Simpson, A.J. , 2012. Monocytes control second-phase neutrophil emigration in established Lipopolysaccharide-induced murine lung injury. Am. J. Respir. Crit. Care Med. . vol. 186. pp. 514-524. (#677)



• Holz, L.E., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G.W., Bowen, D.G., Bertolino, P. , 2012. Naïve CD8 T cells activation by liver bone marrow-derived cells leads to a “neglected” IL-2(low) Bim(high) phenotype, poor CTL function and cell death. J. Hepatol.. vol. 57. pp. 830-836. (#676)



• Bradshaw, A.C., Coughlan, L., Miller, A.M., Alba, R., Van Rooijen, N., Nicklin, S.A., Baker, A.H. , 2012. Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses. J. Control. Release. vol. 164. pp. 394-402. (#674)



• Zhou, D., Chen, Y-T., Chen, F., Gallup, M., Vijmasi, T., Bahrami, A.F., Noble, L.B., Van Rooijen, N., McNamara, N.A. , 2012. Critical involvement of macrophage infiltration in the development of Sjogren’s syndrome-associated dry eye. Am. J. Pathol.. vol. 181. pp. 753-760. (#673)



• Franzke, C.W., Cobzaru, C., Triantafyllopoulou, A., Loffek, S., Horiuchi, K., Threadgill, D.W., Kurz, T., van Rooijen, N., Bruckner-Tuderman, L., Blobel, C.P. , 2012. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J. Exp. Med.. vol. 209. pp. 1105-1119. (#671)



• Kumamaru, H., Saiwai, H., Kobayakawa, K., Kubota, K., Van Rooijen, N., Inoue, K., Iwamoto, Y., Okada, S., 2012. Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures. J. Neuroinflamm.. vol. 9. pp. 116. (#670)



• Choudhry, N., Petry, F., Van Rooijen, N., McDonald, V. , 2012. A protective role for Interleukin 18 in Interferon gamma-mediated innate immunity to Cryptosporidium parvum that is independent of Natural Killer cells. J. Infect. Dis.. vol. 206. pp. 117-124. (#669)



• Boettcher, S., Ziegler, P., Schmid, M.A., Takizawa, H., Van Rooijen, N., Kopf, M., Heikenwalder, M., Manz, M.G. , 2012. LPS-induced emergency myelopoiesis depends on TLR4-expressing non-hematopoietic cells. J. Immunol.. vol. 188. pp. 5824-5828. (#668)



• Maruyama, K., Nakazawa, T., Cursiefen, K., Maruyama, Y., Van Rooijen, N., D’Amore, P.A., Konoshita, S. , 2012. The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. Invest. Ophth. Vis. Sci.. vol. 53. pp. 3145-3153. (#667)



• Barral, P., Sanchez-Nino, M.D., Van Rooijen, N., Cerundolo, V., Batista, F.D. , 2012. The location of splenic NKT cells favours their rapid activation by blood-borne antigen. EMBO J.. vol. 31. pp. 2378-2390. (#666)



• Naessens, T., vander Beken, S., Bogaert, P., Van Rooijen, N., Lienenklaus, S., Weiss, S., DeKoker, S., Grooten, J., 2012. Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypo- to hyperinflammatory reactivity. Am. J. Pathol.. vol. 181. pp. 174-184. (#665)



• Xiang, S., Dong, H-H., Liang, H-F., He, S-Q., Zhang, W., Li, C-H., Zhang, B-X., Zhang, B-H., Jing, K., Tomlinson, S., Van Rooijen, N., Jiang, L., Cianflone, K., Chen, X-P. , 2012. Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat. PLoS One. vol. 7(4). pp. e35180. (#664)



• Elvington, M., Huang, Y., Morgan, B.P., Qiao, F., Van Rooijen, N., Atkinson, C., Tomlinson, S. , 2012. A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood. vol. 119. pp. 6043-6051. (#663)



• Miura, K., Yang, L., Van Rooijen, N., Ohnishi, H., Seki, E. , 2012. Hepatic recruitment of macrophages promotes non-alcoholic steatohepatitis through CCR2. Am. J. Physiol.. vol. 302. pp. G1310-1321. (#662)



• Rakhmilevich, A.L., Baldeshwiler, M.J., Van de Voort, T.J., Felder, M.A.R., Yang, R.K. Kalogriopoulos, N.A., Koslov, D.S., Van Rooijen, N., Sondel, P.M. , 2012. Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects. Cancer Immunol. Immunother. . vol. 61. pp. 1683-1697. (#661)



• Miyairi, I., Ziebarth, J., Laxton, J.D., Wang, X., Van Rooijen, N., Williams, R.W., Lu, L., Byrne, G.I., Cui, Y. , 2012. Host genetics and Chlamydia disease: Prediction and validation of disease severity mechanisms. PLoS One. vol. 7(3). pp. e33781. (#660)



• Silva, S.L., Vaz, A.R., Diogenes, M.J., Van Rooijen, N., Sebastiao, A.M., Fernandes, A., Silva, R.F.M., Brites, D., 2012. Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacol.. vol. 62. pp. 2398-2408. (#659)



• Vinet, J., Van Weering, H.R.J., Heinrich, A., Kalin, R.E., Wegner, A., Brouwer, N., Heppner, F.L., Van Rooijen, N., Boddeke, H.W.G.M., Biber, K., 2012. Neuroprotective function for ramified microglia in hippocampal excitotoxicity. J. Neuroinflamm.. vol. 9. pp. 27 . (#657)



• Weber, S., Tian, H., Van Rooijen, N., Pirofski, L-A. , 2012. A serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibody requires Fcgamma receptor III and macrophages to mediate protection against pneumococcal pneumonia in mice. Infect. Immun.. vol. 80. pp. 1314-1322. (#656)



• Chen, F., Liu, Z., Wu, W., Rozo, C., Bowdridge, S., Millman, A., Van Rooijen, N., Urban, Jr. J.F., Wynn, T.A., Gause, W.C. , 2012. An essential role for the Th2-type responses in limiting acute tissue damage during experimental helminth infection. Nature Medicine. vol. 18. pp. 260-266. (#655)



• Anderson, A.L., Zheng, Y., Song, D., LaRosa, D., Van Rooijen,N., Kierstein, G., Kierstein, S., Haczku, A., Levinson, A.I. , 2012. The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins. Inflamm. Res.. vol. 61. pp. 161-169. (#654)



• Boulter, L., Govaere, O., Bird, T.G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R.A., Seo, S.S., Spee, B., Van Rooijen, N., Sansom, O.J., Iredale, J.P., Lowell, S., Roskams, T., Forbes, S.J. , 2012. Macrophage derived Wnt signalling opposes Notch signaling in a Numb mediated manner to specify HPC fate in chronic liver disease in human and mouse. Nature Medicine. vol. 18. pp. 572-579. (#653)



• Gliem, M., Mausberg, A.K., Lee, J-I., Simiantonakis, I., van Rooijen, N., Hartung, H-P., Jander, S. , 2012. Macrophages prevent hemorrhagic infarct transformation in murine stroke models. Ann. Neurol.. vol. 71. pp. 743-752. (#652)



• Linde, N., Lederle, W., Depner, S., Van Rooijen, N., Gutschalk, C.M., Mueller, M.M. , 2012. Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages. J. Pathol.. vol. 227. pp. 17-28. (#651)



• Mawhinney, L.A., Thawer, S.G., Lu, W-Y., Van Rooijen, N., Weaver, L.C., Brown, A., Dekaban, G.A. , 2012. Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of the lys-EGFP-ki transgenic mouse. J. Neuropathol. Exp. Neurol.. vol. 71. pp. 180-197. (#650)



• Landoni, V.I., Chiarella, P., Martire-Greco, D., Schierloh, P., Van Rooijen, N., Rearte, B., Palermo, M.S., Isturiz, M.A., Fernandez, G.C. , 2012. Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular traps formation leading to a more efficient bacterial clearance in mice. Clin. Exp. Immunol.. vol. 168. pp. 153-163. (#649)



• Garaude, J., Kent, A., Van Rooijen, N., Blander, J.M. , 2012. Simultaneous targeting of Toll- and Nod-like receptors induces effective tumor-specific immune responses. Science Translation. Med.. vol. 4. pp. 120ra16. (#648)



• Honke, N., Shaabani, N., Cadeddu, G., Sorg, U.R., Zhang, D.E., Trilling, M., Klingel, K., Sauter, M., Kandolf, R., Gailus, N., van Rooijen, N., Burkart, C., Baldus, S.E., Grusdat, M., Lohning, M., Hengel, H., Pfeffer, K., Tanaka, M., Haussinger, D., Recher, M., Lang, P.A., Lang, K.S. , 2012. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nature Immunology. vol. 13. pp. 51-57. (#646)



• Robbins, C.S., Chudnovskiy, A., Rauch, P.J., Figueiredo, J.L., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G.F., Ueno, T., van Rooijen, N., Mulligan-Kehoe, M.J., Libby, P., Nahrendorf, M., Pittet, M.J., Weissleder, R., Swirski, F.K., 2012. Extramedullary hematopoiesis generates Ly-6Chigh monocytes that infiltrate atherosclerotic lesions. Circulation. vol. 125. pp. 364-374. (#644)



• Jonsson, F., Mancardi, D.A., Zhao, W., Kita, Y., Iannascoli, B., Khun, H., Van Rooijen, N., Shimizu, T., Schwartz, L.B., Daeron, M., Bruhns, P. , 2012. Human Fc gamma RIIA induces anaphylactic and allergic reactions. Blood. vol. 119. pp. 2533-2544. (#643)



• Drabek, T., Janata, A., Jackson, E.K., End, B., Stezoski, J., Vagni, V.A., Janesko-Feldman, K., Wilson, C.D., van Rooijen, N., Tisherman, S.A., Kochanek, P.M. , 2012. Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. Resuscitation. vol. 83. pp. 517-526. (#637)



• Ingersoll, M.A., Potteaux, S., Alvarez, D., Hutchison, S.B., Van Rooijen, N., Randolph, G.J. , 2012. Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis. Immunobiology. vol. 217. pp. 548-557. (#631)

2011:

• Gommet, C., Billecocq, A., Jouvion, G., Hasan, M., Zaverucha do Valle, T., Guillemot, L., Blanchet, C., Van Rooijen, N., Montagutelli, X., Bouloy, M., Panthier, J.J., 2011. Tissue tropism and target cells of NSs-deleted Rift Valley fever virus in live immunodeficient mice. PLoS Negl. Trop. Dis.. vol. 5(12). pp. e1421. (#647)



• Moldobaeva, A., Van Rooijen, N., Wagner, E.M. , 2011. Effects of ischemia on lung macrophages. PLoS One. vol. 6(11). pp. e26716. (#645)



• Fischer, M.A., Davies, M.L., Reider, I.E., Heipertz, E.L., Epler, M.R., Sei, J.J., Ingersoll, M.A., Van Rooijen, N., Randolph, G.J., Norbury, C.C., 2011. CD11b+ , Ly6G+ Cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection. PLoS Pathog.. vol. 7(11). pp. e1002374. (#642)



• Schwandt, T., Schumak, B., Gielen, G.H., Jungerkes, F., Schmidbauer, P., Klocke, K., Staratschek-Jox, A., van Rooijen, N., Kraal, G., Ludwig-Portugall, I., Franken, L., Wehner, S., Kalff, J.C., Weber, O., Kirschning, C., Coch, C., Kalinke, U., Wenzel, J., Kurts, C., Zawatzky, R., Holzmann, B., Layland, L., Schultze, J.L., Burgdorf, S., den Haan, J.M., Knolle, P.A., Limmer, A. , 2011. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J.. vol. 31. pp. 201-213. (#641)



• Strait, R.T., Hicks, W., Barasa, N., Mahler, A., Khodoun, M., Kohl, J., Stringer, K., Witte, D., Van Rooijen, N., Susskind, B.M., Finkelman, F.D. , 2011. MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice. J. Exp. Med.. vol. 208. pp. 2525-2544. (#640)



• Arroba, A.I., Alvarez-Lindo, N., Van Rooijen, N., de la Rosa, E.J. , 2011. Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa. Invest. Opthalmol. Vis. Res.. vol. 52. pp. 9124-9130. (#639)



• Sakoda, Y., Anand, S., Zhao, Y., Park, J-J., Liu, Y.,Kuramasu, A., Van Rooijen, N., Chen, L., Strome, S.E., Hancock, W.W., Chen, L., Tamada, K. , 2011. Herpesvirus entry mediator regulates hypoxia-inducible factor 1 alpha and erythropoiesis in mice. J. Clin. Invest. . vol. 121. pp. 4810-4819. (#638)



• Hu, Z., Van Rooijen, N., Yang, Y-G. , 2011. Macrophages prevent human red blood cell reconstitution in immuodeficient mice. Blood. vol. 118. pp. 5938-5946. (#636)



• Quattrocchi, V., Langellotti, C., Pappalardo, J.S., Olivera, V., Di Giacomo, S., van Rooijen, N., Mongini, C., Waldner, C., Zamorano, P.I. , 2011. Role of macrophages in early protective immune responses induced by two vaccines against foot and mouth disease. Antiviral Res.. vol. 92. pp. 262-270. (#635)



• Benseler, V., Warren, A., Vo, M., Holz, L.E., Tay, S.S., Le Couteur, D.G., Breen, E., Allison, A.E., Van Rooijen, N., McGuffog, C., Schlitt, H.J., Bowen, D.G., McCaughan, G.W., Bertolino, P.J. , 2011. Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc. Natl. Acad. Sci. USA. vol. 108. pp. 16735-16740. (#634)



• Lanthier, N., Molendi-Coste, O., Cani, P.D., Van Rooijen, N., Horsmans, Y., Leclercq, I.A., 2011. Kupffer cell depletion prevents but has no therapeutic impact on metablic and inflammatory changes induced by a high fat diet. FASEB J.. vol. 25. pp. 4301-4311. (#633)



• Feng, B., Jiao, P., Nie, Y., Kim, T., Jun, D., Van Rooijen, N., Yang, Z., Xu, H. , 2011. Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice. PLoS One. vol. 6(9). pp. e24358. (#632)



• Westwell-Roper, C., Dai, D.L., Soukhatcheva, G., Potter, K.J., Van Rooijen, N., Ehses, J.A., Verchere, C.B. , 2011. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J. Immunol.. vol. 187. pp. 2755-2765. (#630)



• Koneru, R., Kobiler, D., Lehrer, S., Li, J., Van Rooijen, N., Banerjee, D., Glod, J. , 2011. Macrophages play a key role in early blood brain barrier reformation after hypothermic brain injury. Neurosci. Lett. . vol. 501. pp. 148-151. (#629)



• Esplugues, E., Huber, S., Gagliani, N., Hauser, A.E., Town, T., Wan, Y.Y., O’Connor, W., Rongvaux, A., Van Rooijen, N., Habermann, A.M., Iwakura, Y., Kuchroo, V.K., Kolls, J.K., Bluestone, J.A., Herold, K.C., Flavell, R.A., 2011. Control of TH17 cells occurs in the small intestine. Nature. vol. 475. pp. 514-518. (#628)



• Mourao-Sa, D., Robinson, M.J., Zelenay, S., Sancho, D., Chakravarty, P., Larsen, R., Plantinga, M., Van Rooijen, N., Soares, M.P., Lambrecht, B., Sousa, C.R. , 2011. CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. Eur. J. Immunol.. vol. 41. pp. 3040-3053. (#627)



• Zhao, L., Rose, K.M., Elliott, R., Van Rooijen, N., Weiss, S.R., 2011. Cell-type-specific type 1 interferon antagonism influences organ tropism of murine coronavirus. J. Virol.. vol. 85. pp. 10058-10068. (#626)



• Worthington, Z.E., Van Rooijen, N., Carbonetti, N.H. , 2011. Enhancement of Bortella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract. FEMS Immunol. Med. Microbiol. . vol. 63. pp. 119-128. (#625)



• Van Hul, N., Lanthier, N., Espanol, R., Abarca, J., Van Rooijen, N., Dustin, M., Leclercq, I. , 2011. Kupffer cells influence parenchymal invasion and phenotypic orientation but not the proliferation of liver progenitor cells in a murine model of liver injury. Am. J. Pathol.. vol. 179. pp. 1839-1850. (#624)



• Schliehe, C., Redaelli, C., Engelhardt, S., Fehlings, M., Mueller, M., Van Rooijen, N., Thiery, M., Weller, H., Groettrup, M., 2011. CD8 - dendritic cells and macrophages cross-present PLGA particle-encapsulated antigen in vivo. J. Immunol.. vol. 187. pp. 2112-2121. (#623)



• Lee, S.M., Rosen, S., Weinstein, P., Van Rooijen, N., Noble-Haeusslein, L.J. , 2011. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J. Neurotrauma. vol. 28. pp. 1893-1907. (#622)



• Shi, Y.Y., Wang, Y.S., Zhang, Z.X., Cai, Y., Zhou, J., Hou, H.Y., Van Rooijen, N. , 2011. Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells. Graef. Arch. Clin. Exp. Ophthalmol. . vol. 249. pp. 1667-1679. (#621)



• Gibbons, M.A., MacKinnon, A.C., Ramachandran, P., Duffin, R., Dhaliwal, K., Phythian-Adams, A.T., Van Rooijen, N., Haslett, C., Howie, S.E., Simpson, A.J., Hirani, N., Gauldie, J., Iredale, J.P., Sethi, T., Forbes, S.J. , 2011. Ly6Chi monocytes direct alternatively activated pro-fibrotic macrophage regulation of lung fibrosis. Am. J. Respir. Crit. Care Med. . vol. 184. pp. 569-581. (#620)



• Sitia, G., Iannacone, M., Aiolphi, R., Isogawa, M., Van Rooijen, N., Scozzesi, C., Bianchi, M.E., Von Adrian, U.H., Chisari, F.V., Guidotti, L.G. , 2011. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog.. vol. 7(6). pp. e1002061. (#619)



• Kohler,J., Breitbach, K., Renner, C., Heitsch, A.K., Bast, A., Van Rooijen, N., Vogelgesang, S., Steinmetz, I.l, 2011. NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model. Microbes Infect.. vol. 13. pp. 914-922. (#618)



• Weisser, S.B., Brugger, H.K., Voglmaier, N.S., Van Rooijen, N., Sly, L.M. , 2011. SHIP deficient alternatively activated macrophages protect mice during DSS-induced colitis. J. Leuk. Biol.. vol. 90. pp. 483-492. (#617)



• Flores-Langarica, A., Marshall, J.L., Bobat, S., Mohr, E., Hitchcock, J., Ross, E.A., Coughlan, R.E., Khan, M., Van Rooijen, N., Henderson, I.N., MacLennan, I.C.M., Cunningham, A.F. , 2011. T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella. Eur. J. Immunol.. vol. 41. pp. 2654-2665. (#616)



• Santiago-Raber, M-L., Baudino, L., Alvarez, M., Van Rooijen, N., Nimmerjahn, F., Izui, S. , 2011. TLR7/9-mediated monocytosis and maturation of Gr-1hi inflammatory monocytes towards Gr-1lo resting monocytes implicated in murine lupus. J. Autoimmun.. vol. 37. pp. 171-179. (#615)



• Jenkins, S.J., Ruckerl, D., Cook, P.C., Jones, L.H., Finkelman, F.D., Van Rooijen, N., MacDonald, A.S., Allen, J.E. , 2011. Local macrophage proliferation, rather than recruitment from the blood, is a signature of Th2 inflammation. Science. vol. 332. pp. 1284-1288. (#614)