Publications

2009:

• Clementi, A.H., Gaudy, A.M., Van Rooijen, N., Pierce, R.H., Mooney, R.A., 2009. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 Signaling, and further decreases in insulin signaling. Bioch. Bioph. Acta. vol. 1792. pp. 1062-1072. (#511)



• Larsson, C., Lundqvist, J., Van Rooijen, N., Bergstrom, S. , 2009. A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. Plos Neglected Trop. Dis. . vol. 3(9). pp. e522. (#510)



• Holub, M., Cheng, C-W., Mott, S., Wintermeyer, P., Van Rooijen, N., Gregory, S.H. , 2009. Neutrophils sequestered in the liver suppress the proinflammatory response of Kupffer cells to systemic bacterial infection. J. Immunol.. vol. 183. pp. 3309-3316. (#509)



• Majeti, R., Chao, M.P., Alizadeh, A.A., Pang, W.W., Jaiswal, S., Gibbs Jr., K.D., Van Rooijen, N., Weissmman, I.L. , 2009. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. vol. 138. pp. 286-299. (#508)



• Lee, P.Y., Li, Y., Kumagai, Y., Xu, Y.,Weinstein, J.S., Kellner, E.S., Nacionales, D.C., Butfiloski, E.J., Van Rooijen, N., Akira, S., Sobel, E.S., Satoh, M., Reeves, W.H., 2009. Type-1 interferon modulates monocyte recruitment and maturation in chronic inflammation. Am. J. Pathol.. vol. 175. pp. 2023-2033. (#507)



• Fink, K., Ng, C., Nkenfou, C., Vasudevan, S., Van Rooijen, N., Schul, W. , 2009. Depletion of macrophages in mice results in higher dengue virus titers and highlights the rol of macrophages for virus control. Eur. J. Immunol.. vol. 39. pp. 2809-2821. (#506)



• Mircescu, M.M., Lipuma, L., Van Rooijen, N., Pamer, E.G., Hohl, T.M. , 2009. Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. J. Infect. Dis. vol. 200. pp. 647-656. (#505)



• Ye, Z., Kerschen, E.J., Cohen, D.A., Kaplan, A.M., Van Rooijen, N., Straley, S.C. , 2009. Gr1+ cells control growth of YopM-negative Yersinia pestis during systemic plague. Infect. Immun. . vol. 77. pp. 3791-3806. (#504)



• Markovic, D.S., Vinnakota, K., Chirasani, S., Synowitz, M., Wisniewski, P., Lehmann, S., Kalin, R., Van Rooijen, N., Holmbeck, K., Heppner, F.L., Kiwit, J., Lehnardt, S., Kaminska, B., Glass, R., Kettenmann, H. , 2009. Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc. Natl. Acad. Sci. USA. vol. 106. pp. 12530-12535. (#503)



• Betting, D.J., Yamada, R.E., Kafi, K., Said, J., Van Rooijen, N., Timmerman, J.M. , 2009. Intratumoral but not systemic delivery of CpG oligodeoxynucleotide augments the efficacy of anti-CD20 monoclonal antibody therapy against B cell lymphoma. J. Immunotherapy. vol. 32. pp. 622-631. (#502)



• Ashley, S.L., Welton, A.R., Harwood, K.M., Van Rooijen, N., Spindler, K.R. , 2009. Mouse adenovirus type 1 infection of macrophages. Virology. vol. 390. pp. 307-314. (#501)



• Kirby, A.C., Beattie, L., Maroof, A., Van Rooijen, N., Kaye, P.M., 2009. SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis following L. donovani-induced loss of marginal zone macrophages. Am. J. Pathol.. vol. 175. pp. 1107-1115. (#500)



• Wernli, G., Hasan, W., Bhattacherjee, A., Van Rooijen, N., Smith, P.G. , 2009. Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction. Basic Res. Cardiol. . vol. 104. pp. 681-693. (#499)



• Lu, P., Li, L., Liu, G., Van Rooijen, N., Mukaida, N., Zhang, X. , 2009. Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Cornea. vol. 28. pp. 562-569. (#498)



• Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.K., Beck, F.X., Muller, D.N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., Van Rooijen, N., Kurtz, A., Hilgers, K.F., Alitalo, K., Eckardt, K.U., Luft, F.C., Kerjaschki, D., Titze, J. , 2009. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nature Medicine. vol. 15. pp. 545-552. (#497)



• Woodman, M.E., Cooley, A.E., Avdiushko, R., Bowman, A., Botto, M., Wooten, R.M., Van Rooijen, N., Cohen, D.A., Stevenson, B. , 2009. Roles for phagocytic cells and complement in controlling relapsing fever infection. J. Leuk. Biol.. vol. 86. pp. 727-736. (#496)



• Imamura, M., Tsutsui, H., Yasuda, K., Uchiyama, R., Yumikura-Futatsugi, S., Mitani, K., Hayashi, S., Akira, S., Taniguchi, S-I., Van Rooijen, N., Tschopp, J., Yamamoto, T., Fujimoto, J., Nakanishi, K. , 2009. Contribution of TIR domain-containing adapter inducing IFN beta – mediated IL-18 release to LPS-induced liver injury in mice. J. Hepatol.. vol. 51. pp. 333-341. (#495)



• Alba, R., Bradshaw, A.C., Parker, A.L., Bhella, D., Waddington, S.N., Nicklin, S.N., Van Rooijen, N., Custers, J., Goudsmit, J., Barouch, D.H., McVey, J.H., Baker, A.H. , 2009. Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: Effect of mutagenesis on FX interactions and gene transfer. Blood. vol. 114. pp. 965-971. (#494)



• Donnelly, D.J., Gensel, J.C., Ankeny, D.P., Van Rooijen, N., Popovich, P.G., 2009. An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology. J. Neurosci. Methods. vol. 181. pp. 36-44. (#493)



• Wan, H., Coppens, J.M.C., Van Helden-Meeuwsen, C.G., Leenen, P.J.M., Van Rooijen, N., Khan, N.A., Kiekens, R.C.M., Benner, R., Versnel, M.A. , 2009. Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function. J. Leuk. Biol.. vol. 86. pp. 361-370. (#492)



• Perrigoue, J.G., Saenz, S.A., Siracusa, M.C., Allenspach,E.J., Taylor, B.C., Giacomin, P.R., Nair, M.G., Du, Y., Zaph, C., Van Rooijen, N., Comeau, M.R., Pearce, E.J., Laufer, T.M., Artis, D. , 2009. MHC class II-dependent basophil-CD4+ T cell interactions promote Th2 cytokine-dependent immunity. Nature Immunology. vol. 10. pp. 697-705. (#491)



• Jaiswal, S., Jamieson, C.H.M., Pang, W.W., Park, C.Y., Chao, M.P., Majeti, R., Traver, D., Van Rooijen, N., Weissman, I.L. , 2009. CD47 is up-regulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell. vol. 138. pp. 271-285. (#490)



• Cawood, R., Chen, H.H., Carroll, F., Van Rooijen, N., Bazan-Peregrino, M., Seymour, L.W. , 2009. Use of tissue-specific microRNA to control pathology of wild type adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog.. vol. 5(5). pp. e 1000440. (#489)



• Seki, E., De Minicis, S., Inokuchi, S., Taura, K., Miyai, K., Van Rooijen, N., Schwabe, R.F., Brenner, D.A. , 2009. CCR2 promotes hepatic fibrosis in mice. Hepatology. vol. 50. pp. 185-197. (#488)



• Horst, A.K., Bickert, T., Brewig, N., Ludewig, P., Van Rooijen, N., Schumacher, U., Beauchemin, N., Ito, W.D., Fleischer, B., Wagener, C., Ritter, U. , 2009. CEACAM1+ myeloid cells control angiogenesis in inflammation. Blood. vol. 113. pp. 6726-6736.. (#487)



• Gupta, R., Van Rooijen, N., Sefton, M.V. , 2009. Fate of endothelialized modular constructs implanted in an omental pouch in nude rats. Tissue Eng. Part A. vol. 15. pp. 2875-2887. (#486)



• Di Paolo, N.C., Van Rooijen, N., Shayakhmetov, D.M. , 2009. Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver. Mol. Ther.. vol. 17. pp. 675-684. (#485)



• Gensel, J.C., Nakamura, S., Guan, Z., Van Rooijen, N., Ankeny, D.P., Popovich, P.G. , 2009. Macrophages promote axon regeneration with concurrent neurotoxicity. J. Neuroscience. vol. 29. pp. 3956-3968. (#484)



• Redecha, P., Van Rooijen, N., Torry, D., Girardi, G. , 2009. Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury. Blood. vol. 113. pp. 4101-4109. (#483)



• Wilson, M.R., O’Dea, K.P., Zhang, D., Shearman, A.D., Van Rooijen, N., Takata, M. , 2009. Role of lung-marginated monocytes in an in vivo mouse model of ventilator induced lung injury. Am. J. Respir. Crit. Care Med. . vol. 179. pp. 914-922. (#482)



• Leendertse, M., Willems, R.J.L., Giebelen, I.A.J., Roelofs, J.J.T.H., Van Rooijen, N., Bonten, M.J.M., Van der Poll, T., 2009. Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice. Innate Immunity. vol. 15. pp. 3-12. (#481)



• Hernandez, L., Smirnova, T., Kedrin, D., Wyckoff, J., Stanley, R.E., Cox, D., Muller, W.J., Pollard, J.W., Van Rooijen, N., Segall, J.E. , 2009. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta 1 and CXCL 12. Cancer Res.. vol. 69. pp. 3221-3227. (#480)



• Halin, S., Rudolfsson, S.H., Van Rooijen, N., Bergh, A. , 2009. Extratumoral macrophages promote tumor and vascular growth in an orthopic rat prostate tumor model. Neoplasia. vol. 11. pp. 177-186. (#479)



• Campion, S.N., Tatis-Rios, C., Augustine, L.M., Goedken, M.J., Van Rooijen, N., Cherrington, N.J., Manautou, J.E., 2009. Effect of allyl alcohol on hepatic transporter expression: Zone patterns of expression and role of Kupffer cell function. Toxicol. Appl. Pharmacol.. vol. 236. pp. 49-58. (#478)



• Zandbergen, H.R., Sharma, U.C., Gupta, S., Verjans, J.W.H., Van den Borne, S., Pokharel, S., Van Brakel, T., Duijvestijn, A., Van Rooijen, N., Maessen, J.G., Reutelingsperger, C., Pinto, Y.M., Narula, J., Hofstra, L. , 2009. Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy. J. Cardiovasc. Pharmacol. Ther.. vol. 14. pp. 68-75. (#477)



• Manicone, A.M., Birkland, T.P., Betsuyaku, T., Van Rooijen, N., Lohi, J., Keski-Oja, J., Wang, Y., Skerrett, S.J., Parks, W.C. , 2009. Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas Aeruginosa pneumonia. J. Immunol.. vol. 182. pp. 3866-3876. (#476)



• Eidsmo, L., Allan, R., Caminschi, I., Van Rooijen, N., Heath, W.R., Carbone, F.R. , 2009. Differential migration of epidermal and dermal DCs during skin infection. J. Immunol.. vol. 182. pp. 3165-3172. (#475)



• Pande, K., Ueda, R., Machemer, T., Sathe, M., Tsai, V., Brin, E., Delano, M.J., Van Rooijen, N., McClanahan, T.K., Talmadge, J.E., Moldawer, L.L., Phillips, J.H., Laface, D.M. , 2009. Cancer-induced expansion and activation of CD11b(+)Gr-1(+) cells predispose mice to adenoviral-triggered anaphylactoid-type reactions. Mol. Ther.. vol. 17. pp. 508-515. (#474)



• Roychowdhury, S., McMullen, M.R., Pritchard, M.T., Hise, A.G., Van Rooijen, N., Medof, M.E., Stavitsky, A.B., Nagy, L.E. , 2009. An early complement-dependent and TLR-4 independent phase in the pathogenesis of ethanol-induced liver injury. Hepatology. vol. 49. pp. 1326-1334. (#473)



• Oflazoglu, E., Stone, I.J., Brown, L., Gordon, K.A., Van Rooijen, N., Jonas, M., Law, C.L., Grewal, I.S., Gerber, H.P., 2009. Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40. Brit. J. Cancer. vol. 100. pp. 113-117. (#471)



• Kolaczkowska, E., Grzybec, W., Van Rooijen, N., Piccard, H., Plytycz, B., Arnold, B., Opdenakker, G. , 2009. Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis. J. Leuk. Biol.. vol. 85. pp. 374-381. (#470)



• O’Dea, K.P., Wilson, M.R., Dokpesi, J.O., Wakabayashi, K., Tatton, L., Van Rooijen, N., Takata, M. , 2009. Mobilization and margination of bone marrow Gr-1high monocytes during subclinical endotoxemia predisposes the lungs towards acute injury. J. Immunol.. vol. 182. pp. 1155-1166. (#469)



• Nuki, Y., Matsumoto, M.M., Tsang, E., Young, W.L., Van Rooijen, N., Kurihara, C., Hashimoto, T. , 2009. Roles of macrophages in flow-induced outward vascular remodeling. J. Cereb. Blood Flow Metab. . vol. 29. pp. 495-503. (#468)



• Parker, A.L., Waddington, S.N., Buckley, S.M., Custers, J., Havenga, M.J., Van Rooijen, N., Goudsmit, J., McVey, J.H., Nickin, S.A., Baker, A.H. , 2009. Effect of neutralising sera on factor X-mediated adenovirus serotype 5 gene transfer. J. Virol.. vol. 83. pp. 479-483. (#467)



• Traeger, T., Kessler, W., Hilpert, A., Mikulcak, M., Entleutner, M., Koerner, P., Westerholt, A., Cziupka, K., Van Rooijen, N., Heidecke, C.D., Maier, S. , 2009. Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release. Respiration. vol. 77. pp. 203-213. (#464)



• Wildenberg, M.E., Welzen-Coppens, J.M.C., Van Helden-Meeuwsen, C.G., Bootsma, H., Vissink, A., Van Rooijen, N., Van de Merwe, J.P., Drexhage, H.A., Versnel, M.A. , 2009. Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjogren’s syndrome. Ann. Rheum. Dis.. vol. 68. pp. 420-426. (#435)

2008:

• Brechot, N., Gomez, E., Bignon, M., Khallou-Laschet, J., Dussiot, M., Cazes, A., Alanio-Brechot, C., Durand,M., Philippe, J., Silvestre, J-S., Van Rooijen, N., Corvol, P., Nicoletti, A., Chazaud, B., Germain, S. , 2008. Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice. PLoS One. vol. 3(12). pp. e 3950. (#472)



• Lee, P.Y., Kumagai, Y., Li, Y., Takeuchi, O., Yoshida, H., Weinstein, J., Kellner, E.S., Nacionales, D., Barker, T., Kelly-Scumpia, K., Van Rooijen, N., Kumar, H., Kawai, T., Satoh, M., Akira, S., Reeves, W.H. , 2008. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J. Exp. Med.. vol. 205. pp. 2995-3006. (#466)



• Tang, P.C.Y., Qin, L., Zielonka, J., Zhou, J., Matte-Martone, C., Bergaya, S., Van Rooijen, N., Shlomchik, W.D., Min, W., Sessa, W.C., Pober, J.S., Tellides, G. , 2008. MyD88-dependent superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. J. Exp. Med.. vol. 205. pp. 3159-3171. (#465)



• Galea, I., Felton, L.M., Waters, S., Van Rooijen, N., Perry, V.H., Newman, T.A. , 2008. Immune-to- brain signalling: the role of cerebral CD163-positive macrophages. Neurosci. Lett. . vol. 448. pp. 41-46. (#463)



• Engel, D.R., Maurer, J., Tittel, A., Weisheit, C., Cavlar, T., Schumak, B., Limmer, A., Van Rooijen, N., Trautwein, C., Tacke, F., Kurts, C., 2008. CCR2 mediates homeostatic and inflammatory release of Gr1high monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J. Immunol.. vol. 181. pp. 5264-5271. (#462)



• Okamoto, A., Fujio, K., van Rooijen, N., Tsuno, N.H., Takahashi, K., Tsurui, H., Hirose, S., Elkon, K.B., Yamamoto, K. , 2008. Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice. J. Immunol.. vol. 181. pp. 5264-5271. (#461)



• Farber, K., Synowitz, M., Zahn, G., Vossmeyer, D., Stragies, R., Van Rooijen, N., Kettenmann, H. , 2008. An alpha 5 beta 1 integrin inhibitor attenuates glioma growth. Mol. Cell. Neurosci.. vol. 39. pp. 579-585. (#460)



• Corjon, S., Wortmann, A., Engler, T., Van Rooijen, N., Kochanek, S., Kreppel, F., 2008. Targeting of Adenovirus vectors to the LRP receptor family with the high-affinity ligand RAP via combined genetic and chemical modification of the pIX capsomere. Mol. Ther.. vol. 16. pp. 1813-1824. (#458)



• Horn, K,P., Busch, S, A., Hawthorne, A, L., Van Rooijen, N., Silver, J. , 2008. Another barrier to regeneration in the CNS: Activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. J. Neuroscience. vol. 28. pp. 9330-9341. (#457)



• Bystrom, J., Evans, I., Newson, J., Stables, M., Toor, I., Van Rooijen, N., Crawford, M., Colville-Nash, P., Farrow, S., Gilroy, D.W. , 2008. Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. Blood. vol. 112. pp. 4117-4127. (#455)



• Geiben-Lynn, R., Greenland, J. R., Frimpong-Boateng, K., Van Rooijen, N., Hovav, A-H., Letvin, N. L., 2008. CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. Blood. vol. 112. pp. 4585-4590. (#454)



• Lois, N., Dawson, R., Townend, J., McKinnon, A.D., Smith, G.C., Van ‘t Hof, R., Van Rooijen, N., Forrester, J.V. , 2008. Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents . Brit. J. Ophthalmol.. vol. 92. pp. 1528-1533. (#453)



• Hippen, K.L., Harker-Murray, P., Porter, S.B., Merkel, S.C., Londer, A., Taylor, D.K., Bina, M., Panoskaltsis-Mortari, A., Rubinstein, P., Van Rooijen, N., Golovina, T.N., Suhoski, M.M., Miller, J.S., Wagner, J.E., June, C.H., Riley, J.L., Blazar, B.R. , 2008. Umbilical cord blood regulatory T cell (Treg) expansion and functional effects of tumor necrosis factor receptor (TNFR) family members OX40 and 4-1BB expressed on artificial antigen-presenting cells (aAPCs). Blood. vol. 112. pp. 2847-2857. (#452)



• Ganesh Sivanandam, V., Stephen, S.L., Hernandez—Alcoceba, R., Alzuguren, P., Zabala, M., Van Rooijen, N., Qian, C., Berger, I., Gross, M-L, Prieto, J., Kochanek, S. , 2008. Lethality in an anti-angiogenic tumor gene therapy model upon constitutive but not inducible expression of the soluble vascular endothelial growth factor receptor 1. J. Gene Med.. vol. 10. pp. 1083-1091. (#451)



• Huang, Y., Li, Z., Wang, N., Van Rooijen, N., Cui, Q. , 2008. Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds. BMC Neuroscience. vol. 9. pp. 78. (#450)



• Appledorn, D.M., Patial, S., McBride, A., Godbehere, S., Van Rooijen, N., Parameswaran, N., Amalfitano, A. , 2008. Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. J. Immunol.. vol. 181. pp. 2134-2144. (#449)



• Qiu, H., Fan, Y., Joyee, A.G., Wang, S., Han, X., Bai, H., Jiao, L., Van Rooijen, N., Yang, X., 2008. Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages. J. Immunol.. vol. 181. pp. 2092-2102. (#448)



• Zhou, Z., Barrett, R.P., McClellan, S.A., Zhang, Y., Szliter, E.A., Van Rooijen, N., Hazlett, L.D. , 2008. Substance P delays apoptosis, enhancing keratitis after Pseudomonas aeruginosa infection. Invest. Ophthalmol. Vis. Sci.. vol. 49. pp. 4458-4467. (#447)



• Getts, D.R., Terry, R.L., Teague Getts, M., Muller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I.L., King, N.J.C. , 2008. Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J. Exp. Med.. vol. 205. pp. 2319-2337. (#446)



• Fux, M., Van Rooijen, N., Owens, T. , 2008. Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation. J. Neuroimmunol.. vol. 203. pp. 64-72. (#445)



• Campion, S.N., Johnson, R., Aleksunes, L.M., Goedken, M.J., Van Rooijen, N., Scheffer, G.L., Cherrington, N.J., Manautou, J.E. , 2008. Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. Am. J. Physiol.. vol. 295. pp. G294-G304. (#444)



• Horne, P.H., Zimmerer, J.M., Fisher, M., Lunsford, K.E., Nadasdy, G., Nadasdy, T., Van Rooijen, N., Bumgardner, G.L. , 2008. Critical role of effector macrophages in mediating CD4-dependent alloimmune injury of transplanted liver parenchymal cells. J. Immunol.. vol. 181. pp. 1224-1231. (#443)



• Campbell, S.J., Zahid, I., Losey, P., Law, S., Bilgen, M., Van Rooijen, N., Davis, A.E.M., Anthony, D.C. , 2008. Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord. Neuropharmacol.. vol. 55. pp. 780-787. (#441)



• Theurl, M., Theurl, I., Hochegger, K., Obrist, P., Subramaniam, N., Van Rooijen, N., Schuemann, K., Weiss, G. , 2008. Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression. J. Mol. Med.. vol. 86. pp. 825-835. (#440)



• Bem, R.A., Farnand, A.W., Wong, V., Koski, A., Rosenfeld, M.E., Van Rooijen, N., Frevert, C.W., Martin, T.R., Matute-Bello, G. , 2008. Depletion of resident alveolar macrophages does not prevent FAS-mediated lung injury in mice. Am. J. Physiol.. vol. 295. pp. L314-L325. (#439)



• Van Rooijen N. , 2008. Liposomes for targeting of antigens and drugs: Immunoadjuvant activity and liposome-mediated depletion of macrophages. J. Drug Targeting. vol. 16. pp. 529-534. (#438)



• McGill, J., Van Rooijen, N., Legge, K.L. , 2008. Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J. Exp. Med.. vol. 205. pp. 1635-1646. (#437)



• Roth, K.M., Oghumu, S., Satoskar, A.A., Gunn, J.S., Van Rooijen, N., Satoskar, A.R. , 2008. Respiratory infection with Francisella novicida induces rapid dystrophie cardiac calcinosis (DCC). FEMS Immunol. Med. Microbiol. . vol. 53. pp. 72-78. (#436)



• Zhao, A., Urban Jr, J.F., Anthony, R.M., Sun, R., Stiltz, J., Van Rooijen, N., Wynn, T.A., Gause, W.C., Shea-Donohue, T. , 2008. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology. vol. 135. pp. 217-225. (#434)



• Miselis, N.R., Wu, Z.J., Van Rooijen, N., Kane, A.B. , 2008. Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. Mol. Cancer Ther.. vol. 7. pp. 788-799. (#433)



• Murphy, E.A., Davis, J.M., Brown, A.S., Carmichael, M.D., Carson, J.A., Van Rooijen, N., Chaffar, A., Mayer, E.P. , 2008. Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. Am. J. Physiol.. vol. 294. pp. R1593-R1599. (#432)



• Robertson, C.M., Perrone, E.E., McConnell, K.W., Dunne, W.M., Boody, B., Brahmbhatt, T., Diacovo, M.J., Van Rooijen, N., Hogue, L.A., Cannon, C.L., Buchman, T.G., Hotchkiss, R.S., Coopersmith, C.M. , 2008. Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J. Surg. Res.. vol. 150. pp. 278-285. (#431)



• Lee, P.Y., Weinstein, J.S., Nacionales, D.C., Scumpia, P.O., Li, Y., Butfiloski, E.J., Van Rooijen, N., Moldawer, L.L., Satoh, M., Reeves, W.H. , 2008. A novel type1 IFN–producing cell subset in murine lupus. J. Immunol.. vol. 180. pp. 5101-5108. (#430)



• Kaparakis, M., Walduck, A.K., Price, J.D., Pedersen, J.S., Van Rooijen, N., Pearse, M.J., Wijburg, O.L.C., Strugnell, R.A. , 2008. Macrophages are mediators of gastritis in acute Helicobacter pylori infection in C57BL/6 mice. Infect. Immun.. vol. 76. pp. 2235-2239. (#429)



• Soehnlein, O., Oehmcke, S., Ma, X., Rothfuchs, A.G., Frithiof, R., Van Rooijen, N., Morgelin, M., Herwald, H., Lindbom, L. , 2008. Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein. Eur. Respir. J.. vol. 32. pp. 405-412. (#428)



• Bakker, E.N.T.P., Matlung, H.L., Bonta, P., De Vries, C.J., Van Rooijen, N., Van Bavel, E. , 2008. Blood flow-dependent arterial remodeling is facilitated by inflammation but directed by vasculat tone. Cardiovasc. Res.. vol. 78. pp. 341-348. (#427)



• Kim, H.M., Lee, Y.W., Lee, K.J., Kim, H.S., Cho, S.W., Van Rooijen, N., Guan, Y., Seo, S.H. , 2008. Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs. J. Virol.. vol. 82. pp. 4265-4274. (#426)



• Koh, A.Y., Kohler, J.R., Coggshall, K.T., Van Rooijen, N., Pier, G.B. , 2008. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog.. vol. 4(2). pp. e35. (#425)



• Huang, Y., Cen, L-P., Luo, J-M., Wang, N., Zhang, M-Z., van Rooijen, N., Pang, C.P., Cui, Q. , 2008. Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension. Neuroscience. vol. 153. pp. 214-225. (#424)



• Moraes, L.B., Murakami, A.H., Fontes, B., Poggetti, R.S., Van Rooijen, N., Younes, R.N., Heimbecker, A.M., Birolini, D. , 2008. Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event. J. Trauma. vol. 64. pp. 1196-1201. (#423)



• Waddington, S.N., McVey, J.H., Bhella, D., Parker, A.L., Barker, K., Atoda, H., Pink, R., Buckley, S.M.K., Greig, J.A., Denby, L., Custers, J., Morita, T., Francischetti, I.M.B., Monteiro, R.Q., Barouch, D.H., Van Rooijen, N., Napoli, C., Havenga, M.J.E., Nicklin, S.A., Baker, A.H. , 2008. Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. vol. 132. pp. 397-409. (#422)



• Jakubzick, C., Tacke, F., Ginhoux, F., Wagers, A.J., Van Rooijen, N., Mack, M., Merad, M. Randolph, G.J. , 2008. Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J. Immunol.. vol. 180. pp. 3019-3027. (#421)



• Fracarollo, D., Galuppo, P., Schraut, S., Kneitz, S., Van Rooijen, N., Ertl, G., Bauersachs, J. , 2008. Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response. Hypertension. vol. 51. pp. 905-914. (#420)



• Rival, C., Theas, M.S., Suescun, M.O., Jacobo, P., Guazzone, V., Van Rooijen, N., Lustig, L. , 2008. Functional and phenotypical characteristics of testicular macrophages in experimental autoimmune orchitis. J. Pathol.. vol. 215. pp. 108-117. (#419)



• Bryer, S.C., Fantuzzi, G., Van Rooijen, N., Koh, T.J. , 2008. Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis annd skeletal muscle regeneration. J. Immunol.. vol. 180. pp. 1179-1188. (#418)



• Wakim, L., Waithman, J., Van Rooijen, N., Heath, W.R., Carbone, F.R. , 2008. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science. vol. 319. pp. 198-202. (#416)



• Pistea, A., Bakker, E.N., Spaan, J.A., Hardeman, M.R., Van Rooijen, N., Vanbavel, E. , 2008. Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: Role of transglutaminases. J. Vasc. Res. . vol. 45. pp. 10-18. (#411)



• Lidbury, B.A., Suhrbier, A., Tarkowski, A., Van Rooijen, N., Mahalingam, S. , 2008. Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus. J. Infect. Dis. vol. 197. pp. 1585-1593. (#403)



• Kelly, M.M., McNagny, K., Williams, D.L., Van Rooijen, N., Maxwell, L., Gwozd, C., Mody, C.H., Kubes, P. , 2008. The lung responds to zymosan in a unique manner independent of Toll-like receptors, complement and dectin-1. Am. J. Respir. Cell Mol. Biol.. vol. 38. pp. 227-238. (#398)

2007:

• Mott, K., Brick, D.J., Van Rooijen, N., Ghiasi, H., 2007. Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice. Invest. Ophthalmol. Vis. Res.. vol. 48. pp. 5605-5615. (#417)



• Fischer, C., Jonckx, B., Mazzone, M., Zacchigna, S., Loges, S., Pattarini, L., Chorianopoulos, E., Liesenborghs, L., Koch, M., De Mol, M., Autiero, M., Wyns, S., Plaisance, S., Moons, L., Van Rooijen, N., Giacca, M., Stassen, J-M., Dewerchin, M., Collen, D., Carmeliet, P, 2007. Anti-PIGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. vol. 131. pp. 463-475. (#414)



• Couper, K.N., Blount, D.G., Hafalla, J.C., Van Rooijen, N., De Souza, J.B., Riley, E.M. , 2007. Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitaemia. Infect. Immun.. vol. 75. pp. 5806-5818. (#413)



• Oflazoglu,, E., Stone, I.J., Gordon, G.A., Grewal, I.S., Van Rooijen, N., Law, C-L., Gerber, H-P. , 2007. Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30. Blood. vol. 110. pp. 4370-4372. (#412)



• Flierl, M.A., Rittirsch, D., Nadeau, B.A., Chen, A.J., Sarma, J.V., Zetoune, F.S., McGuire, S.R., List, R.P., Day, D.E., Hoesel, L.M., Gao, H., Van Rooijen, N., Huber-Lang, M.S., Neubig, R.R., Ward, P.A. , 2007. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature. vol. 449. pp. 721-725. (#410)