Publications

2004:

• Jiang, Z., Schiedner, G., Van Rooijen, N., Liu, C.C., Kochanek, S., Clemens, P.R., 2004. Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade. Mol. Ther.. vol. 10. pp. 688-696. (#306)



• Godau, J., Heller, T., Hawlisch, H., Trappe, M., Howells, E., Best, J., Zwirner, J., Verbeek, J.S., Hogarth, P.M., Gerard, C., Van Rooijen, N., Klos, A., Gessner, J.E., Kohl, J. , 2004. C5a initiates the inflammatory cascade in immune complex peritonitis. J. Immunol.. vol. 173. pp. 3437-3445. (#305)



• Sammels, L.M., Bosio, E., Fragall, C.T., Grounds, M.D., Van Rooijen, N., Beilharz, M.W., 2004. Innate inflammatory cells are not responsible for early death of donor myoblasts after myoblast transfer therapy. . Transplantation. vol. 77. pp. 1790-1797. (#304)



• Murphy, E.A., Davis, J.M., Brown,A.S., Carmichael, M.D., Van Rooijen, N., Chaffar, A., Mayer, E.P., 2004. Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. Am. J. Physiol.. vol. 287. pp. R1354-1358. (#303)



• Blom, A.B., Van Lent, P.L., Holthuysen, A.E., Van Der Kraan, P.M., Roth, J., Van Rooijen, N., Van Der Berg, W.B. , 2004. Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage. vol. 12. pp. 627-635. (#302)



• Chen, Y., Lui, V.C.H., Van Rooijen, N., Tam, P.K.H., 2004. Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Gut. vol. 53. pp. 1772-1780. (#300)



• Gao, H., Guo, R.F., Speyer, C.L., Reuben, J., Neff, T.A., Hoesel, L.M., Riedemann, N.C., McClintock, S.D., Sarma, J.V., Van Rooijen, N., Zetoune, F.S., Ward, P.A., 2004. Stat3 activation in acute lung injury. J. Immunol.. vol. 172. pp. 7703-7712. (#299)



• Hughes, E.H., Schlichtenbrede , F.C., Murphy, C.C., Broderick, C., Van Rooijen, N., Ali, R.R., Dick, A.D., 2004. Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp. Eye Res.. vol. 78. pp. 1077-1084. (#298)



• Silva, G.C., Nagib, P.R.A., Chiari, E., Van Rooijen, N., Machado, C.R.S., Camargos, E.R.S., 2004. Peripheral macrophage depletion reduces central nervous system parasitism and damage in Trypanosoma cruzi – infected suckling rats. J. Neuroimmunol.. vol. 149. pp. 50-58. (#297)



• Sunderkotter, C., Nikolic, T., Dillon, M.J., Van Rooijen, N., Stehling, M., Drevets, D.A., Leenen, P.J.M. , 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol.. vol. 172. pp. 4410-4417. (#296)



• Drevets, D.A., Dillon, M.J., Schawang, J.S., Van Rooijen, N., Ehrchen, J., Sundercotter, C., Leenen, P.J.M., 2004. The Ly-6C high monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J. Immunol.. vol. 172. pp. 4418-4424. (#295)



• Wolff, R.A., Tomas, J.T., Hullett, D.A., Stark, V.E., Van Rooijen, N., Hoch, J.R. , 2004. Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta-1 in healing rat vein grafts. J. Vasc. Surg.. vol. 39. pp. 878-888. (#294)



• Lee, A.M., Fryer, A.D., Van Rooijen, N., Jacoby, D.B., 2004. The role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction. Am. J. Physiol.. vol. 286. pp. L1255-1259. (#293)



• Marin-Teva, J.L., Dusart, I., Colin, C., Gervais, A., Van Rooijen, N., Mallat, M. , 2004. Microglia promote the death of developing Purkinje cells. Neuron. vol. 41. pp. 535-547. (#292)



• Slegers, T.P.A.M., Broersma, L., Van Rooijen, N., Hooymans, J.M.M., Van Rij, G., Van der Gaag, R. , 2004. Macrophages play a role in the early phase of corneal allograft rejection in rats. Transplantation. vol. 77. pp. 1641-1646. (#291)



• Muhlen, K.A., Schumann, J., Wittke, F., Stenger, S., Van Rooijen, N., Van Kaer, L., Tiegs, G., 2004. NK cells but not NKT cells are involved in Pseudomonas aeruginosa exotoxin A - induced hepatoxicity in mice. J. Immunol.. vol. 172. pp. 3034-3041. (#290)



• Jasinski, M., Pantazopoulos, P., Rother, R.P., Van Rooijen, N., Song, W.C., Molina, H., Bessler, M. , 2004. A novel mechanism of complement independent clearance of red cells deficient in glycosyl phosphatidylinositol linked proteins. Blood. vol. 103. pp. 2827-2834. (#289)



• Van Lent, P.L.E.M., Blom, A.B.,Van der Kraan, P., Holthuyzen, A.E.M., Vitters, E., Van Rooijen, N., Smeets, R.L., Nabbe, K.C.A.M., Van den Berg, W.B. , 2004. Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis Rheum.. vol. 50. pp. 103-111. (#286)

2003:

• Schiedner, G., Bloch, W., Hertel, S., John,M., Molojavyi, A., Dries, V., Varga, G., Van Rooijen, N., Kochanek, S. , 2003. A hemodynamic response to intravenous adenovirus vector particles is caused by systemic kupffer cell-mediated activation of endothelial cells. Human Gene Therapy. vol. 14. pp. 1631-1641. (#288)



• Stager, S., Alexander, J., Kirby, A.C., Botto, M., Van Rooijen, N., Smith, D.F., Brombacher, F., Kaye, P.M. , 2003. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nature Medicine. vol. 9. pp. 1287-1292. (#287)



• Emoto, M., Miyamoto, M., Emoto, Y., Yoshizawa, I., Brinkmann, V., Van Rooijen, N., Kaufmann, S.H.E. , 2003. Highly biased type-1-immune responses in mice deficient in LFA-1 in Listeria monocytogenes infection are caused by elevated IL-12 production by granulocytes. . J. Immunol.. vol. 171. pp. 3970-3976. (#285)



• Saeij, J.P.J., Groeneveld, A., Van Rooijen, N., Haenen, O.L.M., Wiegertjes, G.F. , 2003. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Dis. Aquat. Organ. . vol. 57. pp. 67-75. (#284)



• Jose, M.D., Ikezumi, Y., Van Rooijen, N., Atkins, R.C., Chadban, S.J. , 2003. Macrophages act as effectors of tissue damage in acute renal allograft rejection. Transplantation. vol. 76. pp. 1015-1022. (#283)



• Naidu, B.V., Krishnadasan, B., Farivar, A.S., Woolley,S.M., Thomas, R., Van Rooijen, N., Verrier, E.D., Mulligan, M.S. , 2003. Early activation of the alveolar macrophage is critical to the development of lung ischemia-reperfusion injury. J. Thorac. Cardiovasc. Surg. . vol. 126. pp. 200-207. (#282)



• Van Rooijen, N., Van Kesteren-Hendrikx, E., 2003. "In vivo" depletion of macrophages by liposome-mediated "suicide".. Methods in Enzymology. vol. 373. pp. 3-16. (#281)



• Nolte, M.A., Belien, J.A.M., Schadee-Eestermans, I., Jansen,W., Unger, W.W.J., Van Rooijen, N., Kraal, G., Mebius, R.E. , 2003. A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp. J. Exp. Med.. vol. 198. pp. 505-512. (#280)



• Emoto, M.,Emoto, Y., Brinkmann, V., Miyamoto, M.,Yoshizawa, I., Staber, M. Van Rooijen, N., Hamann, A., Kaufmann, S.H.E., 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: A novel role for LFA-1 in the regulation of the pro-inflammatory and anti-inflammatory cytokine balance.. J. Immunol.. vol. 171. pp. 584-593. (#279)



• Sakurai, E., Anand, A., Ambati, B.K., Van Rooijen, N., Ambati, J. , 2003. Macrophage depletion inhibits experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. . vol. 44. pp. 3578-3585. (#278)



• Masztalerz, A., Van Rooijen, N., Den Otter, W., Everse, L.A. , 2003. Mechanism of macrophage cytotoxicity in IL-2 and IL-12 mediated tumour regression. Cancer Immunol. Immunother. . vol. 52. pp. 235-242. (#277)



• Sheikh, N.A., Attard, G.S., Van Rooijen, N., Rajananthanan, P., Hariharan, H., Yang, Y.W, Morrow, W.J.W., 2003. Differential requirements for CTL generation by novel immunostimulants: APC tropism, use of the TAP independent processing pathway and dependency on CD80/CD86 costimulation . Vaccine. vol. 21. pp. 3775-3788. (#276)



• McClellan, S.A., Huang, X., Barrett, R.P., Van Rooijen, N., Hazlett, L.D. , 2003. Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx and balance pro- and anti-inflammatory cytokines in BALB/c mice. J. Immunol. . vol. 170. pp. 5219-5227. (#275)



• Slegers, T.P.A.M., Van der Veen, G., Hermans, L.J.A., Broersma, L., Van Rooijen, N.,Volker-Dieben, H.J., Van Rij, G., Van der Gaag, R., 2003. Adhesion molecule expression in local macrophage depleted rats bearing orthotopic corneal allografts. Graef. Arch. Clin. Exp. Ophthalmol. . vol. 241. pp. 432-438. (#274)



• Belnoue, E., Costa, F. T. M., Vigario, A.M., Voza, T., Gonnet, F., Landau, I., Van Rooijen, N., Mack, M., Kuziel, W.A., Renia, L, 2003. Chemokine Receptor CCR2 is not essential for the development of experimental cerebral malaria. Infect. Immun. . vol. 71. pp. 3648-3651. (#273)



• Kraal, G., Van Rooijen, N, 2003. Reaching the macrophage: Routes of delivery. In “The macrophage as therapeutic target”.. Handbook of Experimental Pharmacology. vol. 158. pp. 55-65. (#272)



• Rivas, C., Djeraba, A., Musset, E., Van Rooijen, N., Baaten, B., Quere, P., 2003. Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (Cl2MBP) suppresses nitric oxide production and reduces genetic resistance to Marek’s disease. Avian Pathology. vol. 32. pp. 139-149. (#271)



• Schiedner, G., Hertel, S., Johnston, M., Dries, V., Van Rooijen, N., Kochanek, S. , 2003. Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors.. Mol. Ther.. vol. 7. pp. 35-43. (#270)



• Selzner, N., Selzner, M., Odermatt, B., Tian, Y., Van Rooijen, N., Clavien, P.-A. , 2003. ICAM 1 triggers liver regeneration through leukocyte recruitment and Kupffer cell dependent release of TNF-alpha/IL-6 in mice.. Gastroenterology. vol. 124. pp. 692-700. (#269)



• Popovich, P.G., van Rooijen, N., Hickey, W.F., Preidis, G., McGaughy, V. , 2003. Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury.. Exp. Neurol.. vol. 182. pp. 275-287. (#268)



• Yi, S., Hawthorne, W.J., Lehnert, A.M., Ha, H., Kwok Wah Wong, J., Van Rooijen, N., Davey, K., Patel, A.T., Walters, S.N., Chandra, A., O’Connell, P.J. , 2003. T cell activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J. Immunol. . vol. 170. pp. 2750-2758. (#267)



• Slegers, T., Van der Gaag, R., Van Rooijen, N., Van Rij, G., Streilein, W. , 2003. Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts. Curr. Eye Res. . vol. 26. pp. 73-79. (#266)



• Alves-Rosa, F., Vermeulen, M., Cabrera, J., Stanganelli, C., Capozzo, A., Narbaitz, M., Van Rooijen, N., Palermo, M., Isturiz, M.A. , 2003. Macrophage depletion following liposomal encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice.. Brit. J. Haematol. . vol. 121. pp. 130-138. (#265)



• Wu, G., Korsgren, O., Sun, S., Van Rooijen, N., Tibell, A. , 2003. Effect of plasma exchange in combination with deoxyspergualin on the survival of guinea pig hearts in macrophage-depleted C6-deficient rats.. Xenotransplantation. vol. 10. pp. 214-222. (#263)



• Knapp, S., Leemans, J.C., Florquin, S., Branger, J., Maris, N.A., Pater, J.M., Van Rooijen, N., Van Der Poll, T. , 2003. Alveolar macrophages have a protective anti-inflammatory role during murine pneumococcal pneumonia.. Am. J. Respir. Crit. Care Med. . vol. 167. pp. 171-179. (#262)



• Dickson, B.C., Yang, H., Savelkoul, H.F.J., Rowden, G., Van Rooijen, N., Wright Jr, J.R , 2003. Islet transplantation in the discordant tilapia-to-mouse model: A novel application of alginate microencapsulation in the study of xenograft rejection.. Transplantation. vol. 75. pp. 599-606. (#261)



• Chuah, M.K.L., Schiedner, G., Thorrez, L., Brown, B., Johnston, M., Gillijns, V., Hertel, S., Van Rooijen, N., Lillicrap, D., Collen, D., VandenDriessche, T., Kochanek, S., 2003. Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors.. Blood. vol. 101. pp. 1734-1743. (#260)



• Omer, A., Keegan, M., Czismadia, E., De Vos, P., Van Rooijen, N., Bonner-Weir, S., Weir, G.C. , 2003. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. vol. 10. pp. 240-251. (#255)



• Jordan, M.B., Van Rooijen, N., Izui, S., Kappler, J., Marrack, P., 2003. Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model. Blood. vol. 101. pp. 594-601. (#244)

2002:

• Sedger, L.M., Hou, S.M., Osvath, S.R., Glaccum,M.B., Peschon, J.J., Van Rooijen, N., Hyland, L., 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.. J. Immunol.. vol. 169. pp. 6193-6201. (#264)



• Belnoue, E., Kayibanda, M., Vigario, A.M., Deschemin, J-C., Van Rooijen, N., Viguier, M., Snounou, G., Renia, L. , 2002. On the pathogenic role of brain-sequestered alpha-beta CD8+ T cells in experimental cerebral malaria.. J. Immunol.. vol. 169. pp. 6369-6375. (#259)



• Wijburg, O.L.C., Van Rooijen, N., Strugnell, R.A. , 2002. Induction of CD8+ T lymphocytes by Salmonella typhimurium is independent of Salmonella pathogenicity island 1-mediated host cell death.. J. Immunol.. vol. 169. pp. 3275-3283. (#258)



• Gregory, S.H., Cousens, L.P., Van Rooijen, N., Dopp, E.A., Carlos, T.M., Wing, E.J. , 2002. Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J. Immunol.. vol. 168. pp. 308-315. (#257)



• Guo, R.F., Lentsch, A.B., Vidya Sarma, J., Sun, L., Riedemann, N.C., McClintock, S.D., McGuire, S.R., Van Rooijen, N., Ward, P.A. , 2002. Activator protein-1 activation in acute lung injury. Am. J. Pathol.. vol. 161. pp. 275-282. (#256)



• Knudsen, E., Iversen, P.O., Van Rooijen, N., Benestad, H.B. , 2002. Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat. Eur. J. Haematol.. vol. 69. pp. 284-296. (#254)



• Djeraba, A., Musset, E., Van Rooijen, N., Quere, P. , 2002. Resistance and susceptibility to Marek’s disease: nitric oxide synthase/arginase activity balance. Vet. Microbiol.. vol. 86. pp. 229-244. (#253)



• Kolaczkowska, E., Shahzidi S., Seljelid. R., Van Rooijen, N., Plytycz, B., 2002. Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: Crucial involvement of macrophage-derived cysteinyl-leukotrienes. Inflammation. vol. 26. pp. 61-71. (#252)



• Kielian, T., Van Rooijen, N., Hickey, W.F. , 2002. MCP-1 expression in CNS-1 astrocytoma cells: implications for macrophage infiltration into tumors in vivo. J. Neuro-Oncology. vol. 56. pp. 1-12. (#251)



• Polfliet, M.M.J., Van de Veerdonk, F., Dopp, E.A., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K. , 2002. Perivascular and meningeal macrophages play a role during the onset of experimental allergic encephalomyelitis. J. Neuroimmunol.. vol. 122. pp. 1-8. (#250)



• Marshall, J., McEachern, K., Kyros, J., Nietupski, J., Budzinski, T., Ziegler, R., Yew, N., Sullivan, J., Scaria, A., Van Rooijen, N., Barranger, J., Cheng, S. , 2002. Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model. Mol. Ther.. vol. 6. pp. 179-189. (#249)



• Ziegler, R.J., Li, C., Cherry, M., Zhu, Y., Hempel, D., Van Rooijen, N., Ioannou, Y.A., Desnick, R.J., Goldberg, M.A., Yew, N.S., Cheng, S.H. , 2002. Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. . Human Gene Therapy. vol. 13. pp. 935-945.. (#248)



• Bauer, D., Schmitz, A., Van Rooijen, N., Steuhl, K-P., Heiligenhaus, A, 2002. Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus 1 infection. Immunology. vol. 107. pp. 118-128. (#246)



• Haeberle,H.E., Takizawa, R., Casola, A., Brasier, A.R., Dieterich, H.J., Van Rooijen, N., Gatalica, Z., Garofalo, R.P, 2002. Respiratory syncytial virus-induced activation of Nuclear Factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4 - dependent pathways.. J. Infect. Dis. vol. 186. pp. 1199-1206. (#245)



• Alves-Rosa, F., Stanganelli, C., Cabrera, J.,Cymberknop, D., Rubel, C., Vanzulli, S., Van Rooijen, N., Palermo, M., Isturiz, M.A, 2002. Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia.. Brit. J. Haematol.. vol. 116. pp. 357-366. (#243)



• Van Rooijen N., Van Kesteren-Hendrikx, E., 2002. Clodronate liposomes: perspectives in research and therapeutics. J. Liposome Research. vol. 12. pp. 81-94. (#242)

2001:

• Wu, G.S., Korsgren, O., Van Rooijen, N., Tibell, A., 2001. Suppression of T cells results in long-term survival of mouse heart xenografts in C6-deficient rats. Xenotransplantation. vol. 8. pp. 303-309. (#247)



• Laverman, P., Carstens, M.G., Boerman, O.C., Dams, E.Th.M., Oyen, W.J.G., Van Rooijen, N., Corstens, F.H.M., Storm, G., 2001. Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection. J. Pharm. Exp. Ther.. vol. 298. pp. 607-612. (#239)



• Moreno, A., Badell, E., Van Rooijen, N., Druilhe, P., 2001. Human malaria in immunocompromised mice: new in vivo model for chemotherapy studies. Antimicrob. Agents. Chemother.. vol. 45. pp. 1847-1853. (#238)



• Teeling, J.L., Bleeker, W.K., Rigter, G.M.M., Van Rooijen, N., Kuijpers, T.W., Hack, C.E., 2001. Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages - studies in a rat model. Brit. J. Haematol.. vol. 112. pp. 1031-1040. (#237)



• Kotter, M.R., Setzu, A., Sim, F.J.,Van Rooijen, N., Franklin, R.J.M., 2001. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia. vol. 35. pp. 204-212. (#236)



• Hayley, S., Lacosta, S., Merali, Z., Van Rooijen, N., Anisman, H., 2001. Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects. Eur. J. Neurosci.. vol. 13. pp. 1155-1165. (#235)



• Polfliet, M.M.J., Goede, P.H., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K., 2001. A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system. J. Neuroimmunol.. vol. 116. pp. 188-195. (#234)



• Zito, M.A., Koennecke, L.A., McAuliffe, M.J., McNally, B., Van Rooijen, N., Heyes, M.P., 2001. Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates striatal macrophage invasion and neurodegeneration following local endotoxin infusion in gerbils. Brain Res.. vol. 892. pp. 13-26. (#233)



• Everse, L.A., Anderson, L.D., Van Rooijen, N., Mullen, C.A., 2001. Bone marrow transplant conditioning intensified with liposomal clodronate to eliminate residual host antigen presenting cells fails to ameliorate GVHD and increases PERI-BMT mortality. Transplantation. vol. 71. pp. 611-618. (#232)



• Polfliet, M.M.J., Zwijnenburg, P.J.G., Van Furth, A.M., Van Der Poll, T., Dopp, E.A., Renardel De Lavalette, C., Van Kesteren-Hendrikx, E.M.L., Van Rooijen, N., Dijkstra, C.D., Van den Berg, T.K., 2001. Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. J. Immunol.. vol. 167. pp. 4644-4650. (#231)



• Salez, L., Balloy, V., Van Rooijen, N., Lebastard, M., Touqui, L., McCormack, F.X., Chignard, M., 2001. Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages. J. Immunol.. vol. 166. pp. 6376-6382. (#230)



• Guillot, C., Coathalem, H., Chetritt, J., David, A., Lowenstein, P., Gilbert, E., Tesson, L., Van Rooijen N., Cuturi, M.C., Soulillou, J.P., Anegon, I., 2001. Lethal hepatitis after gene transfer of IL-4 in the liver is independent of immune responses and dependent on apoptosis of hepatocytes: a rodent model of IL-4 induced hepatitis. J. Immunol.. vol. 166. pp. 5225-5235. (#229)



• Leemans, J.C., Juffermans, N.P., Florquin, S., Van Rooijen, N., Vervoordeldonk, M.J., Verbon, A., Van Deventer, S.J.H., Van der Poll, T., 2001. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol.. vol. 166. pp. 4604-4611. (#228)



• Tang, C., Inman, M.D., Van Rooijen, N., Yang, P., Shen, H., Matsumoto, K., O'Byrne, P.M., 2001. Th type 1-stimulating activity of lung macrophages inhibits Th 2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism. J. Immunol.. vol. 166. pp. 1471-1481. (#227)



• Bauer, D., Mrzyk, S., Van Rooijen, N., Steuhl, K.P, Heiligenhaus, A., 2001. Incidence and severity of herpetic stromal keratitis: Impaired by the depletion of lymph node macrophages. Exp. Eye Res.. vol. 72. pp. 261-269. (#226)



• Lehner, M.D., Ittner, J., Bundschuh, D.S., Van Rooijen, N., Wendel, A., Hartung, T., 2001. Improved innate immunity. of endotoxin-tolerant mice increases resistance to Salmonella enterica Serovar Typhimurium infection despite attenuated cytokine response.. Infect. Immun.. vol. 69. pp. 463-471. (#225)

2000:

• Honing, H., Van Rooijen, N., Van Den Berg, T.K., 2000. Manipulation of macrophage activities using liposomes. J. Liposome Research. vol. 10. pp. 359-389. (#224)



• Rutkowski, M.D., Pahl, J.L., Sweitzer, S., Van Rooijen, N., DeLeo, J.A., 2000. Limited role of macrophages in the generation of nerve injury-induced mechanical allodynia. Physiol. Behavior.. vol. 71. pp. 225-235. (#223)



• Zhang-Hoover, J., Sutton, A., Van Rooijen, N., Stein-Streilein, J., 2000. A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis. Immunology. vol. 101. pp. 501-511. (#222)



• Ciavarra, R.P., Greene, A.R., Horeth, D.R., Buhrer, K., Van Rooijen, N., Tedeschi, B., 2000. Antigen processing of vesicular stomatitis virus in situInterdigitating dendritic cells present viral antigens independent of marginal dendritic cells but fail to prime CD4+ and CD8+ T cells.. Immunology. vol. 101. pp. 512-520. (#221)



• Emoto, M., Miyamoto, M., Namba, K., Schmits, R., Van Rooijen, N., Kita, E., Kaufmann, S.H.E., 2000. Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver. Eur. J. Immunol.. vol. 30. pp. 3049-3056. (#220)



• Badell, E., Oeuvray, C., Moreno, A., Soe, S., Van Rooijen, N., Bouzidi, A., Druilhe, P., 2000. Human malaria in immunocompromised mice: an in vivo model to study defense mechanisms against Plasmodium Falciparum.. J. Exp. Med.. vol. 192. pp. 1653-1659. (#219)



• Sekine Y., Yasufuku, K., Heidler, K.M., Cummings, O.W., Van Rooijen, N., Fujisawa, T, Brown, J., Wilkes, D.S., 2000. Monocyte Chemoattractant Protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. Am. J. Respir. Cell Mol. Biol.. vol. 23. pp. 719-726. (#218)



• Schumann, J., Wolf, D., Pahl, A., Brune, K., Papadopoulos, T., Van Rooijen, N., Tiegs, G., 2000. Importance of Kupffer cells for T cell-dependent liver injury in mice. Am. J. Pathol.. vol. 157. pp. 1671-1683. (#217)



• Miyamoto, M., Emoto, M., Brinkmann, V., Van Rooijen, N., Schmits, R., Kita, E., Kaufmann, S.H.E., 2000. Contribution of NK cells to the homing of thymic CD4+NKT cells to the liver. J. Immunol.. vol. 165. pp. 1729-1732. (#216)



• Alves-Rosa, F., Stanganelli, C., Cabrera, J., Van Rooijen, N., Palermo, M.S., Isturiz, M.A., 2000. Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune. thrombocytopenic purpura in a mouse model.. Blood. vol. 96. pp. 2834-2840. (#215)



• Van Overdam, K.A., Verbakel. C.A.E., Kouwenhoven, E.A., Van Rooijen, N., De Bruin, R.W.F., Ijzermans, J.N.M., Marquet, R.L., 2000. Negligible role for NK cells and macrophages in delayed xenograft rejection. Transplant. Int.. vol. 13, (Suppl.1). pp. S504-S507. (#214)



• Wu, G., Korsgren, O., Zhang, J., Song, Z., Van Rooijen, N., Tibell, A., 2000. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation. vol. 7. pp. 214-220. (#213)



• Barrera, P., Blom, A., Van Lent, P.L.E.M., Van Bloois, L., Storm, G., Beijnen, J., Van Rooijen, N., Van De Putte, L.B.A., Van Den Berg, W.B., 2000. Synovial macrophage depletion with clodronate containing liposomes in rheumatoid arthritis. Arthritis Rheum.. vol. 43. pp. 1951-1959. (#212)



• Cheng, H., Tumpey, T.M., Staats, H.F., Van Rooijen, N., Oakes, J.E., Lausch, R.N., 2000. Role of macrophages in restricting Herpes Simplex Virus Type 1 growth after ocular infection. Invest. Ophthalmol. Vis. Res.. vol. 41. pp. 1402-1409. (#211)



• Van der Hoek, K.H., Maddocks, S., Woodhouse,C.M., Van Rooijen, N., Robertson, S.A., Norman, R.J., 2000. Intrabursal injection of clodronate liposomes causes macrophage depletion and inhibits ovulation in the mouse ovary. Biol. Reproduct.. vol. 62. pp. 1059-1066. (#210)



• Slegers, T.P.A.M., Torres, P.F., Broersma, L., Van Rooijen, N., Van Rij, G., Van der Gaag, R., 2000. Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats. Invest. Ophthalmol. Vis. Res.. vol. 41. pp. 2239-2247. (#209)



• Slegers, T.P.A.M., Van Rooijen, N., Van Rij, G., Van der Gaag, R., 2000. Delayed corneal graft rejection in high-risk eyes after subconjunctival injection of clodronate liposomes. Curr. Eye Res.. vol. 20. pp. 322-324. (#208)



• Meijer, C., Wiezer, M.J., Diehl, A.M., Yang, S-Q., Schouten, H.J., Meijer, S., Van Rooijen, N., Van Lambalgen, A.A., Dijkstra, C.D., Van Leeuwen, P.A.M., 2000. Kupffer cell depletion by Cl2MDP-liposomes alters hepatic cytokine expression and delays liver regeneration after partial hepatectomy. Liver. vol. 20. pp. 66-77. (#207)



• Wijburg. O.L.C., Simmons, C.P., Van Rooijen, N. Strugnell, R.A., 2000. Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. typhimurium infections in mice.. Eur. J. Immunol.. vol. 30. pp. 944-953. (#206)



• Westerhuis, R., Van Straaten, S.C., Van Dixhoorn, M.G.A., Van Rooijen, N., Verhagen, N.A.M., Dijkstra, C.D., De Heer, E., Daha, M.R., 2000. Distinctive roles of neutrophils and monocytes in anti-Thy-1 nephritis. Am. J. Pathol.. vol. 156. pp. 303-310. (#205)



• Vajdova,K., Smrekova, R., Kukan, M., Jakubovsky, J., Van Rooijen, N., Horecky, J., Lutterova, M., Wsolova, L., 2000. Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. J. Hepatol.. vol. 32. pp. 112-120. (#204)