Publications

2000:

• Galeazzi, F., Haapala, E.M., Van Rooijen, N., Vallance, B.A., Collins, S.M., 2000. Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am. J. Physiol.. vol. 278. pp. G259-G265. (#203)



• Liu, T., Van Rooijen, N., Tracey, D.J., 2000. Depletion of macrophages reduces axonal degeneration and hyperalgesia following nerve injury. Pain. vol. 86. pp. 25-32. (#202)



• Laverman, P., Brouwers, A.H., Oyen, W.J.G., Dams, E.Th.M., Van Rooijen, N., Corstens, F.H.M., Storm, G., Boerman, O.C., 2000. Dose effect of stealth-liposomes; disappearance of long-circulating characteristics at low lipid dose. J. Pharm. Exp. Ther.. vol. 293. pp. 996-1001. (#201)



• Bauer, D., Mrzyk, S., Van Rooijen, N., Steuhl, K.P., Heiligenhaus, A., 2000. Macrophage-depletion influences the course of murine HSV-1 keratitis. Curr. Eye Res.. vol. 20. pp. 45-53. (#200)



• Van Rooijen, N., Van Kesteren-Hendrikx, E., 2000. Analysis of macrophage activity in vivo. In: "Macrophages: A practical approach". Ed: D.M. Paulnock, Oxford University Press, Oxford, UK.. pp. 157-172. (#199)

1999:

• Wijburg, O.L.C., Strugnell, R.A. and Van Rooijen, N., 1999. Macrophages in viral immunity. Regulation of acquired immune responses.. Current Topics in Virology. vol. 1. pp. 127-138. (#240)



• Trostdorf, F., Bruck, W., Schmitz-Salue, M., Stuertz, K., Hopkins, S.J., Van Rooijen, N., Huitinga, I., Nau, R., 1999. Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis. J. Neuroimmunol.. vol. 99. pp. 205-210. (#198)



• Torres, P.F., Slegers, T.P.A.M., Peek, R., Van Rooijen, N., Van der Gaag, R., Kijlstra, A., De Vos, A.F., 1999. Changes in cytokine mRNA levels in experimental corneal allografts after local clodronate-liposome treatment. Invest. Ophthalmol.. vol. 40. pp. 3194-3201. (#197)



• Koennecke, L.A., Zito, M.A., Proescholdt, M.G., Van Rooijen, N., Heyes, M.P., 1999. Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates increases in brain quilonic acid during CNS-localized and systemic immune activation. J. Neurochem.. vol. 73. pp. 770-779. (#196)



• Wu, G., Korsgren, O., Van Rooijen, N., Wennberg, L., Tibell, A., 1999. The effect of macrophage depletion on delayed xenograft rejection: Studies in the guinea pig to C6-deficient rat heart transplantation model. Xenotransplantation. vol. 6. pp. 262-270. (#195)



• Lentsch, A.B., Czermak, B.J., Bless, N.B., Van Rooijen, N., Ward, P.A., 1999. Essential role of alveolar macrophages in intrapulmonary activation of NF-kB. Am. J. Respir. Cell Mol. Biol.. vol. 20. pp. 692-698. (#194)



• Popovich, P.G., Guan, Z., Wei, P., Huitinga, I., Van Rooijen, N., Stokes, B.T., 1999. Depletion of hematogenous macrophages promotes partial neurologic recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol.. vol. 158. pp. 351-365. (#193)



• Palermo, M.S., Alves Rosa, M.F., Van Rooijen, N., Isturiz, M.A., 1999. Depletion of liver and splenic macrophages reduces the lethality of Shiga toxin-2 in a mouse model. Clin. Exp. Immunol.. vol. 116. pp. 462-467. (#192)



• Kradin, R.L., Liu, H.W., Van Rooijen, N., Springer, K., Zhao, L.H., Leary, C.P., 1999. Pulmonary immunity to Listeria is enhanced by elimination of alveolar macrophages. Am. J. Respir. Crit. Care Med.. vol. 159. pp. 1967-1974. (#191)



• Kopydlowski, K.M., Salkowski, C.A., Cody, M.J., Van Rooijen, N., Major, J., Hamilton, T.A., Vogel, S.N., 1999. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo. J. Immunol.. vol. 163. pp. 1537-1544. (#190)



• Kodukula, P., Liu, T., Van Rooijen, N., Jager, M.J., and Hendricks, R.L., 1999. Macrophage control of Herpes Simplex Virus Type 1 replication in the peripheral nervous system. J. Immunol.. vol. 162. pp. 2895-2905. (#189)



• Jun, H.S., Yoon, C.S., Zbytnuik, L., Van Rooijen, N., and Yoon, J.W., 1999. The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice. J. Exp. Med.. vol. 189. pp. 347-358. (#188)



• Jiang, Q., DeTolla, L., Singh, I.S., Gatdula, L., Fitzgerald, B., Van Rooijen, N., Cross, A,S., and Hasday, J.D., 1999. Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. Am. J. Physiol.. vol. 276. pp. 1653-1660. (#187)



• Jiang, Q., DeTolla, L., Van Rooijen, N., Singh, I.S., Fitzgerald, B., Lipsky, M.M., Kane, A.S., Cross, A,S., and Hasday, J.D., 1999. Febrile-range temperature modifies early systemic TNFa expression in mice challenged with bacterial endotoxin. Infect. Immun.. vol. 67. pp. 1539-1546. (#186)



• Xue, S., Sun, N., Van Rooijen, N., Perlman, S., 1999. Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus. J. Virol.. vol. 73. pp. 6327-6334. (#185)



• Hoch, J.R., Stark, V.K., Van Rooijen, N., Kim, J.l., Nutt, M.P., Warner, T.F., 1999. Macrophage depletion alters vein graft intimal hyperplasia. Surgery. vol. 126. pp. 428-437. (#184)



• Hanson, L.K., Slater, J.S., Karabekian, Z., Virgin, H.W., Biron, C.A., Ruzek, M.C., Van Rooijen, N., Ciavarra, R.P., Stenberg, R.M., Campbell, A.E., 1999. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis. J. Virol.. vol. 73. pp. 5970-5980. (#183)



• Schughart, K., Bischoff, R., Ali Hadji, D., Boussif, O., Perraud, F., Accart, N., Rasmussen, U.B., Pavirani, A., Van Rooijen, N. and Kolbe, H.V.J., 1999. Effect of liposome-encapsulated clodronate pretreatment on synthetic vector-mediated gene expression in mice. Gene Therapy. vol. 6. pp. 448-453. (#182)

1998:

• Mielcarek, N., Nordstrom, I., Van Rooijen, N., Menozzi, F.D., Locht, C. and Holmgren, J., 1998. Effect of alveolar macrophage depletion during Bordetella pertussis infection in C57bl/6 mice: decreased bacterial clearance and modified immune responses. Proc. 10th Int. Congr. Immunology (G.P.Talwar, I.Nath, N.K.Ganguly, K.V.S.Rao, eds.), New Delhi. pp. 1023-1027. (#180)



• Dunstan, S.J., Simmons, C.P., Wijburg, O.L.C., Uren, T.K., Van Rooijen, N., and Strugnell, R.A., 1998. Studies of the pathogenesis and immunology of attenuated mutants of Salmonella enterica var. Typhimurium: lessons for human typhoid fever?. Med. J. Indonesia. vol. vol.7 (suppl.1). pp. 74-80. (#179)



• Fox, A., Koulmanda,M., Mandel, T.E., Van Rooijen, N., Harrison, L.C., 1998. Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation. vol. 66. pp. 1407-1416. (#178)



• Van Der Veen, G., Broersma, L., Van Rooijen, N., Van Rij, G. and Van Der Gaag, R., 1998. Cytotoxic T lymphocytes and antibodies after orthotropic penetrating keratoplasty in rats treated with dichloromethylene diphosphonate encapsulated liposomes. Curr. Eye Res.. vol. 17. pp. 1018-1026. (#177)



• Tran, E.H., Hoekstra, K., Van Rooijen, N., Dijkstra, C.D. and Owens, T., 1998. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J. Immunol.. vol. 161. pp. 3767-3775. (#176)



• Pouvreau, I., Zech, J-C., Thillaye-Goldenberg, B., Naud, M.C., Van Rooijen, N., De Kozak, Y., 1998. Effect of macrophage depletion by liposomes containing dichloromethylene diphosphonate on endotoxin-induced uveitis. J. Neuroimmunol.. vol. 86. pp. 171-181. (#175)



• Stein, C.S., Pemberton, J.L., Van Rooijen, N. and Davidson, B.L., 1998. Effects of macrophage depletion and anti-CD40L ligand on transgene expression and redosing with recombinant adenovirus. Gene Therapy. vol. 5. pp. 431-439. (#174)



• Oussoren, C., Velinova, M., Scherphof, G., Van der Want, J.J., Van Rooijen, N., Storm, G., 1998. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection IV. Fate of liposomes in regional lymph nodes.. Bioch. Bioph. Acta. vol. 1370. pp. 259-272. (#173)



• Bakker, J., Sanders, A., Van Rooijen, N., 1998. Effects of liposome-encapsulated drugs on macrophages: comparative activity of the diamidine 4',6-diamidino-2-phenylindole and the phenanthridinium salts ethidium bromide and propidium iodide. Bioch. Bioph. Acta. vol. 1373. pp. 93-100. (#172)



• Jeurissen, S.H.M., Janse, E.M., Van Rooijen, N., Claassen, E., 1998. Inadequate anti-polysaccharide antibody responses in the chicken. Immunobiology. vol. 198. pp. 385-395. (#171)



• Claassen, I.J.T.M., Osterhaus, A.D.M.E., Poelen, M., Van Rooijen, N., Claassen, E., 1998. Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen, II Cellular, but not humoral, systemic immune responses against rabies virus immune-stimulating complexes are macrophage dependent.. Immunology. vol. 94. pp. 455-460. (#170)



• Leenen, P.J.M., Radosevic, K., Voerman, J.S.A., Salomon, B., Van Rooijen, N., Klatzmann, D. and Van Ewijk, W., 1998. Heterogeneity of mouse spleen dendritic cells: In vivo phagocytic activity, expression of macrophage markers and subpopulation turnover. J. Immunol.. vol. 160. pp. 2166-2173. (#169)



• Gregory, S.H., Wing, E.J., Danowski, K.L., Van Rooijen, N., Dyer, K.F. and Tweardy, D.J., 1998. IL-6 Produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic Listerial infections. J. Immunol.. vol. 160. pp. 6056-6061. (#168)



• Van Lent, P.L.E.M., Holthuyzen, A.E.M., Van Rooijen, N., Van De Putte, L.B.A. and Van Den Berg, W.B., 1998. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann. Rheum. Dis.. vol. 57. pp. 408-413. (#167)



• Van Lent, P.L.E.M., Holthuyzen, A.E.M., Van Rooijen, N., Van De Loo, F.A.J., Van De Putte, L.B.A. and Van Den Berg, W.B., 1998. Phagocytic synovial lining cells regulate acute and chronic joint inflammation after antigenic exacerbation of smouldering experimental murine arthritis. J. Rheumatol.. vol. 25. pp. 1135-1145. (#166)



• Verstegen, M.M.A., Van Hennik, P.B., Terpstra, W., Van Den Bos, C., Wielenga, J.J., Van Rooijen, N., Ploemacher, R.E., Wagemaker, G. and Wognum, A.W., 1998. Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice: evidence for accessory cell involvement in expansion of immature CD34+CD38- cells. Blood. vol. 91. pp. 1966-1976. (#165)



• Wijburg, O.L.C., Van den Dobbelsteen, G.P.J.M., Vadolas, J., Sanders, A., Strugnell, R.A. and Van Rooijen, N., 1998. The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens. Eur. J. Immunol.. vol. 28. pp. 479-487. (#164)



• Straub, R.H., Dorner, M., Riedel, J., Van Rooijen, N., Lang, B., Scholmerich, J. and Falk, W., 1998. Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen is mediated by opioidergic transmission. Am. J. Physiol.. vol. 43. pp. R997-R1003. (#163)



• Van Rooijen, N., 1998. Liposomes. In: Encyclopedia of Immunology (Second Edition). Eds. I.M. Roitt and P.J. Delves. Academic Press Ltd. London, UK.. pp. 1588-1592. (#162)



• Van Rooijen, N. and Sanders, A., 1998. Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine: Synergistic and antagonistic effects of liposomal phospholipids and drugs. Int. J. Pharmaceut.. vol. 162. pp. 51-58. (#161)



• Van Rooijen, N. and Sanders, A., 1998. The macrophage as target or obstacle in liposome-based targeting strategies. Int. J. Pharmaceut.. vol. 162. pp. 45-50. (#160)

1997:

• Wijburg, O.L.C., DiNatale, S., Vadolas, J., Van Rooijen, N. and Strugnell, R.A., 1997. Alveolar macrophages regulate the induction of primary cytotoxic T-lymphocyte responses during Influenza virus infection. J. Virol.. vol. 71. pp. 9450-9457. (#159)



• Wijburg, O.L.C., Heemskerk, M.H.M., Boog,C.J.P. and Van Rooijen, N., 1997. Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59. Immunology. vol. 92. pp. 252-258. (#158)



• Terpstra, W., Leenen, P.J.M., Van den Bos, C., Prins, A., Loenen, W.A.M., Verstegen, M.M.A., Van Wijngaardt, S., Van Rooijen, N., Wognum, A.W., Wagemaker, G., Wielenga, J.J. and Lowenberg, B., 1997. Facilitated engraftment of human hematopoietic cells in severe combined immunodeficient mice following a single injection of Cl2MDP liposomes. Leukemia. vol. 11. pp. 1049-1054. (#157)



• Sekine, Y., Bowen, L.K., Heidler, K.M., Van Rooijen, N., Brown, J.W., Cummings, O.W. and Wilkes, D.S., 1997. Role of passenger leukocytes in allograft rejection: Effect of depletion of donor alveolar macrophages on the local production of TNF-a, Th1/Th2 cytokines, IgG subclasses and pathology in a rat model of lung transplantation. J. Immunol.. vol. 159. pp. 4084-4093. (#156)



• Pena-Rossi, C., Delcroix, M., Huitinga, I., McAllister, A., Van Rooijen, N., Claassen, E., Brahic, M., 1997. Role of macrophages during Theiler's virus infection. J. Virol.. vol. 71. pp. 3336-3340. (#155)



• Hirunpetcharat, C., Tian, J.H., Kaslow, D.C., Van Rooijen, N., Kumar, S., Berzofsky, J.A., Miller, L.H. and Good, M.F., 1997. Complete protective immunity induced in mice by immunization with the 19kDa carboxylterminal fragment of the merozoite surface protein-1 (MSP119) of Plasmodium yoelii expressed in Saccharomyces cerevisiae: Correlation of protection with antigen-specific a. J. Immunol.. vol. 159. pp. 3400-3411. (#154)



• Gaytan, F., Bellido, C., Aguilar, R., Morales, C., Van Rooijen, N. and Aguilar, E., 1997. Role of the testis in the response of the pituitary-testicular axis to NO-related agents. Eur. J. Endocrinol.. vol. 137. pp. 301-308. (#153)



• Feith, G.W., Bogman, M.J.J.T., Assmann, K.J.M., Van Gompel, A.P.M., Schalkwijk, J., Van Rooijen, N., Koene, R.A.P., 1997. Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN dependent anti-GMB nephritis in mice. Exp. Nephrol.. vol. 5. pp. 301-304. (#152)



• Ciavarra, R.P., Buhrer, K., Liuzzi, F.J., Van Rooijen, N., Tedeschi, B., 1997. T Cell priming against vesicular stomatitis virus analyzed in situ: I. Red pulp macrophages but not marginal metallophilic or marginal zone macrophages are required for priming CD4+ and CD8+ T cell.. J. Immunol.. vol. 158. pp. 1749-1755. (#151)



• Nieuwenhuijzen, G.A.P., Knapen, M.F.C.M., Hendriks, T., Van Rooijen, N., Goris, R.J.A., 1997. Elimination of various subpopulations of macrophages and the development of the multiple organ dysfunction syndrome in mice. Arch. Surgery. vol. 132. pp. 533-539. (#150)



• Van Andel, R.A., Hook, R.R., Franklin, C.L., Besch-Williford, C.L., Van Rooijen, N., Riley, L.K., 1997. Effects of neutrophil, natural killer cell and macrophage depletion on murine Clostridium piliforme infection. Infect. Immunity. vol. 65. pp. 2725-2731. (#149)



• Wijburg, O.L.C., DiNatale, S., Strugnell, R.A., Van Rooijen, N., 1997. The role of alveolar macrophages in induction of primary cytotoxic T lymphocyte responses during influenza virus infection. In: "Mucosal solutions: advances in mucosal immunology" Eds. AJ Husband, KW Beagley, RL Clancy, AM Collins, AW Cripps, DL Emery, University of Sydney, ISBN 1 86451 289 X. . vol. 1. pp. 289-300. (#148)



• Salkowski, C.A., Detore, G., McNally, R., Van Rooijen, N., Vogel, S.N., 1997. Regulation of inducible nitric oxide synthase messenger RNA expression and nitric oxide production by lipopolysaccharide in vivo: The roles of macrophages, endogenous IFN-g and TNF receptor-1-mediated signaling. J. Immunol.. vol. 158. pp. 905-912. (#147)



• Espenes,A., Press, C.McL., Van Rooijen,N., Landsverk,T., 1997. Apoptosis in phagocytic cells of lymphoid tissues in rainbow trout (Oncorhynchus mykiss) following administration of clodronate liposomes. Cell Tissue Res.. vol. 289. pp. 323-331. (#146)



• Chung, Y.H., Jun, H.S., Kang, Y., Hirasawa, K., Lee, B.R., Van Rooijen, N. and Yoon, J.W., 1997. Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats. J. Immunol.. vol. 159. pp. 466-471. (#145)



• Zysk, G., Bruck, W., Huitinga, I., Fischer, F.R., Flachsbarth, F., Van Rooijen, N., Nau, R., 1997. Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis. J. Neuroimmunol.. vol. 73. pp. 77-80. (#144)



• Samsom, J.N., Annema, A, Groeneveld, P.H.P., Van Rooijen, N., Langermans, J.A.M., Van Furth, R., 1997. Elimination of resident macrophages from the livers and spleens of immune mice impairs acquired resistance against a secondary Listeria monocytogenes infection. Infect. Immun.. vol. 65. pp. 986-993. (#143)



• Sundstedt, A., Hoiden, I., Rosendahl, A., Kalland, T., Van Rooijen, N., Dohlsten, M., 1997. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol.. vol. 158. pp. 180-186. (#142)



• Rudnicka, W., Wieckowska, M., Van Rooijen, N., Rozalska, B., 1997. The immune response to staphylococcal antigens in mice depleted of macrophages by Cl2MDP-liposomes. Zentralblatt fur Mikrobiologie. vol. 286. pp. 511-522. (#141)



• Reinders, M.E., Van Wagensveld, B.A., Van Gulik, T.M., Corssmit, N.P.M., Frederiks, W.M., Chamuleau, R.A.F.M., Van Rooijen, N., Obertop, H., 1997. No attenuation of ischemic and reperfusion injury in Kupffer cell-depleted, cold preserved rat livers. Transplantation. vol. 63. pp. 449-454. (#140)



• Worgall, S., Leopold, P.L., Wolff, G., Ferris, B., Van Rooijen, N., Crystal, R.G., 1997. Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. Human Gene Therapy. vol. 8. pp. 1675-1684. (#139)



• Wolff, G., Worgall, S., Van Rooijen, N., Song, W-R., Harvey, B-G., Crystal, R.G., 1997. Enhancement of in vivo Adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J. Virol.. vol. 71. pp. 624-629. (#138)



• Leenen, P.J.M., Voerman, J.S.A., Radosevic, K., Van Rooijen, N., Van Ewijk, W., 1997. Mouse spleen dendritic cells: phagocytic activity and expression of macrophage markers. Adv. Exp. Med. Biol.. vol. 417. pp. 91-95. (#137)



• Leenaars, P.P.A.M., Savelkoul, H.F.J., Hendriksen, C.F.M., Van Rooijen, N., Claassen, E., 1997. Increased adjuvant efficacy in stimulation of antibody responses after macrophage elimination in vivo. Immunology. vol. 90. pp. 337-343. (#136)



• Broekhuyse, R.M., Huitinga, I., Kuhlmann, E.D., Van Rooijen, N., Winkens, H.J., 1997. Differential effect of macrophage depletion on two forms of experimental uveitis evoked by pigment epithelial membrane protein (EAPU), and by melanin-protein (EMIU). Exp. Eye Res.. vol. 65. pp. 841-848. (#135)



• Van Rooijen, N. and Sanders, A., 1997. Elimination, blocking and activation of macrophages: three of a kind? J. J. Leuk. Biol.. vol. 62. pp. 702-709. (#134)



• Van Rooijen, N., Bakker, J., Sanders, A., 1997. Transient suppression of macrophage functions by liposome-encapsulated drugs. Trends Biotechnol.. vol. 15. pp. 178-185. (#133)

1996:

• Blok, W.L., De Bruijn, M.F.T.R., Leenen, P.J.M., Eling, W.M.C., Van Rooijen, N., Stanley, E.R., Buurman, W.A., Van Der Meer, J.W.M., 1996. Dietary n-3 fatty acids increase spleen size and post-endotoxin circulating tumor necrosis factor in mice: role of macrophages, macrophage precursors, and Colony Stimulating Factor-1. J. Immunol.. vol. 157. pp. 5569-5573. (#132)



• Suda, T., Callahan, R.J., Wilkenson, R.A., Van Rooijen, N., Schneeberger,E.E., 1996. Interferon-g reduces Ia+ dendritic cell traffic to the lung. J. Leuk. Biol.. vol. 60. pp. 519-527. (#131)



• Hu, Q., Van Rooijen, N. and Liu, D., 1996. Effect of macrophage elimination using liposome-encapsulated dichloromethylene diphosphonate on tissue distribution of liposomes. J. Liposome Research. vol. 6. pp. 681-698. (#130)



• Van Lent,P.L.E.M., Holthuyzen,A.E.M., Van Den Bersselaar,L.A.M., Van Rooijen,N., Joosten, L.A.B., Van De Loo,F.A.J., Van De Putte,L.B.A. and Van Den Berg,W.B., 1996. Phagocytic lining cells determine local expression of inflammation in collagen type II arthritis. Arthritis Rheum.. vol. 39. pp. 1545-1555. (#129)



• Van Klink,F., Taylor,W.M., Alizadeh, H., Jager, M.J., Van Rooijen, N. and Niederkorn, J.Y., 1996. The role of macrophages in Acanthamoeba keratitis. Invest. Ophthalm. Vis. Sci.. vol. 37. pp. 1271-1281. (#128)



• Karupiah,G., Buller,R.M.L., Van Rooijen,N., Duarte,C.J. and Chen,J., 1996. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J. Virol.. vol. 70. pp. 8301-8309. (#127)



• Wijburg, O.L.C., Heemskerk, M.H.M., Sanders, A., Boog,C.J.P. and Van Rooijen, N., 1996. Role of virus specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection. Immunology. vol. 87. pp. 34-41. (#126)



• Gaytan, F., Bellido, C., Morales, C., Garcia, M., Van Rooijen, N. and Aguilar, E., 1996. In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects. J. Endocrinol.. vol. 150. pp. 57-65. (#125)



• Ben-Nathan, D., Huitinga, I., Lustig, S., Van Rooijen, N. Kobiler, D., 1996. West-Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice. Arch. Virol.. vol. 141. pp. 459-469. (#124)



• DeHaan, A., Groen, G., Prop, J., Van Rooijen, N., Wilschut, J., 1996. Mucosal immunoadjuvant activity of liposomes: Role of alveolar macrophages. Immunology. vol. 89. pp. 488-493. (#123)



• Buiting,A.M.J., Zhou,F., Bakker,J.A.J., Van Rooijen,N. and Huang,L., 1996. Biodistribution of clodronate and liposomes used in the liposome mediated macrophage . J. Immunol. Meth.. vol. 192. pp. 55-62. (#122)



• Buiting,A.M.J., De Rover,Z., Kraal,G., Van Rooijen,N., 1996. Humoral immune responses against particulate bacterial antigens are dependent on marginal metallophilic macrophages in the spleen. Scand. J. Immunol.. vol. 43. pp. 398-405. (#121)



• Boelen,A., Platvoet-ter Schiphorst,M.C., Van Rooijen,N., Wiersinga,W.M., 1996. Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse. Eur. J. Endocrinol.. vol. 134. pp. 513-518. (#120)



• Bayon,L.G., Izquierdo, M.A., Sirovich,I., Van Rooijen,N., Beelen,R.H.J. and Meijer,S., 1996. Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver. Hepatology. vol. 23. pp. 1224-1231. (#119)



• Van Rooijen,N., Wijburg,O.L.C., Van Den Dobbelsteen, G.P.J.M. and Sanders, A., 1996. Macrophages in host defense mechanisms. In: "Immunology of silicones", M.Potter & N.R.Rose eds.Springer-Verlag, Berlin; Curr. Top. Microbiol. Immunol.. vol. 210. pp. 159-165. (#118)



• Van Rooijen,N., Sanders,A., Van den Berg,T., 1996. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of drugs. J. Immunol. Meth.. vol. 193. pp. 93-99. (#117)



• Van Rooijen,N., Sanders,A., 1996. Kupffer cell depletion by liposome-delivered drugs: Comparative activity of intracellular clodronate, propamidine and ethylenediaminetetraacetic acid (EDTA). Hepatology. vol. 23. pp. 1239-1243. (#116)



• Van Rooijen,N., 1996. Selective depletion of macrophages by liposome-encapsulated drugs. In: "Handbook of Experimental Immunology" 5e. Herzenberg,L., Herzenberg,L. & Weir,D., Eds. Blackwell Scientific Publications, Inc. USA.. pp. 165.1-165.5. (Chapter 165) . (#115)

1995:

• Vreden, S.G.S., Van den Broek, M.F., Oettinger, M.C., Boers, W., Van Rooijen, N., Meuwissen, J.H.E.T., & Sauerwein, R.W., 1995. Susceptibility to Plasmodium berghei infection in rats is modulated by the acute phase response. Parasite Immunol.. vol. 17. pp. 445-450. (#114)



• Vanderkerken,K., Bouwens,L., Van Rooijen,N., & Wisse,E., 1995. Role of Kupffer cells in the process of differentiation of pit cells in rat liver. In: "Cells of the Hepatic Sinusoid", Eds. E.Wisse, DL.Knook & K.Wake. Kupffer Cell Foundation, Leiden, The Netherlands.. vol. 5. pp. 145-147. (#113)



• Vanderkerken,K., Bouwens,L., Van Rooijen,N., Van den Berg,K., Baekeland,M., & Wisse,E., 1995. The role of Kupffer cells in the differentiation process of hepatic natural killer cells. Hepatology. vol. 22. pp. 283-290. (#112)



• Salkowski,C.A.,Neta,R.,Wynn,T.A.,Strassmann, G.,Van Rooijen,N. and Vogel,S.N., 1995. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J. Immunol.. vol. 155. pp. 3168-3179. (#111)



• Rocha,M., Kruger,A., Van Rooijen,N., Schirrmacher,V. & Umansky,V., 1995. Liver endothelial cells participate in T cell dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo. Int. J. Canc.. vol. 63. pp. 405-411. (#110)



• Fraser,C.C., Chen,B.P., Webb,S., Van Rooijen,N. & Kraal,G., 1995. Circulation of human hemopoietic cells in Severe Combined Immunodeficient mice following Cl2MDP-liposome mediated macrophage depletion. Blood. vol. 86. pp. 183-192. (#109)



• Tarazona, R., Gonzalez-Garcia,A., Zamzami,N., Marchetti,P., Frechin,N., Gonzalo,J.A., Ruiz-Gayo, M., Van Rooijen,N., Martinez-A,C. and Kroemer,G., 1995. Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. J. Immunol.. vol. 154. pp. 861-870. (#108)



• Van Lent,P.L.E.M., Holthuyzen,A.E.M.,Van Den Bersselaar,L.A.M.,Van Rooijen,N., Van De Putte,L.B.A. and Van Den Berg, W.B., 1995. Role of macrophage-like synovial lining cells in localization and expression of experimental arthritis. Scand. J. Rheumatol.(suppl. 101). vol. 24 . pp. 83-89. (#107)



• Schotanus, K., Holtkamp, G.M., Van Rooijen, N., Tilders, F.J.H. and Berkenbosch, F., 1995. Circulating tumor necrosis factor- a does not mediate endotoxin-induced hypothermia in rats. Am. J. Physiol.. vol. 268. pp. R989-R996. (#106)



• Marquet,R.L., Bonthuis,F., Duval, S.Y., DeBruin, R.W.F., Van Rooijen,N., Scheringa,M. and IJzermans J.N.M., 1995. Macrophages and nitric-oxide are involved in primary nonfunction of islet xenografts. Transpl. Proc.. vol. 27. pp. 252-253. (#105)



• Dai,R., Van Rooijen,N., Dijkstra,C.D., and Streilein,J.W., 1995. Relative roles of T cells and macrophages in cytokine-mediated functional transformation of cultured splenic dendritic cells. Cell. Immunol.. vol. 162. pp. 265-274. (#104)