Results

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Sections of mouse liver, stained with monoclonal antibody F4/80

Top: Normal liver with positive Kupffer cells

Bottom: Liver of a mouse, 2 days after injection with clodronate-liposomes. Kupffer cells have been depleted

Sections of mouse spleen stained for acid phosphatase

Top: Normal spleen with positive splenic macrophages

Bottom: Spleen of a mouse 2 days after injection with clodronate liposomes. Only few macrophages are left.